Journal article
Safety analysis of leishmania vaccine used in a randomized canine vaccine/immunotherapy trial
American Journal of Tropical Medicine and Hygiene, Vol.98(5), pp.1332-1338
2018
DOI: 10.4269/ajtmh.17-0888
PMCID: PMC5953386
PMID: 29512486
Abstract
In Leishmania infantum-endemic countries, controlling infection within dogs, the domestic reservoir, is critical to public health. There is a need for safe vaccines that prevent canine progression with disease and transmission to others. Protective vaccination against Leishmania requires mounting a strong, inflammatory, Type 1 response. Three commercially available canine vaccines on the global veterinary market use saponin or inflammatory antigen components (Letifend) as a strong pro-inflammatory adjuvant. There is very little information detailing safety of saponin as an adjuvant in field trials. Safety analyses for the use of vaccine as an immunotherapeutic in asymptomatically infected animals are completely lacking. Leishmania infantum, the causative agent of canine leishmaniasis, is enzootic within U.S. hunting hounds. We assessed the safety of LeishTec® after use in dogs from two different clinical states: 1) without clinical signs and tested negative on polymerase chain reaction and serology or 2) without clinical signs and positive for at least one Leishmania diagnostic test. Vaccine safety was assessed after all three vaccinations to quantify the number and severity of adverse events. Vaccinated animals had an adverse event rate of 3.09%, whereas placebo animals had 0.68%. Receiving vaccine was correlated with the occurrence of mild, site-specific, reactions. Occurrence of severe adverse events was not associated with having received vaccine. Infected, asymptomatic animals did not have a higher rate of adverse events. Use of vaccination is, therefore, likely to be safe in infected, asymptomatic animals.
Details
- Title: Subtitle
- Safety analysis of leishmania vaccine used in a randomized canine vaccine/immunotherapy trial
- Creators
- Angela ToeppMandy LarsonTara Grinnage-PulleyCarolyne BennettMichael AndersonMolly ParrishHailie FowlerGeneva WilsonKatherine Gibson-CorelyRadhika GharpureCaitlin CotterChristine Petersen
- Resource Type
- Journal article
- Publication Details
- American Journal of Tropical Medicine and Hygiene, Vol.98(5), pp.1332-1338
- DOI
- 10.4269/ajtmh.17-0888
- PMID
- 29512486
- PMCID
- PMC5953386
- NLM abbreviation
- Am J Trop Med Hyg
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Language
- English
- Date published
- 2018
- Academic Unit
- Molecular Physiology and Biophysics; Epidemiology; Pathology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983996098502771
Metrics
18 Record Views