Journal article
Safety and Efficacy of Intravascular Lithotripsy in Calcified Left Main Coronary Artery Disease: A Systematic Review and Meta-Analysis
Catheterization and cardiovascular interventions, Vol.106(1), p.336
04/24/2025
DOI: 10.1002/ccd.31554
PMID: 40270001
Abstract
BackgroundIntravascular lithotripsy (IVL) has emerged as a novel therapeutic modality for the management of calcified coronary lesions. The effectiveness and safety of IVL specifically in the context of left main disease remains uncertain and limited. We performed a meta-analysis to consolidate existing data.MethodsOnline databases Medline, Embase, Cochrane were searched for studies using IVL during percutaneous coronary intervention (PCI) of calcified left main disease. The outcomes of interest were procedural success, procedural complications and cardiovascular (CV) events. Pooled proportions with 95% confidence intervals (CI) were calculated using a random-effects model.ResultsA total of 10 studies with 435 patients (mean age 73.1 years, 73.1% males) were included. The pooled outcomes were procedural success 98.8% (95% CI 95.58-100), perforation 0.02% (95% CI 0.00-0.87), major dissection 0.87% (95% CI 0.00-3.97), slow-flow/no-reflow 0.27% (95% CI 0.00-1.47) and abrupt vessel closure 0.01% (95% CI 0.00-1.01). In-hospital CV events were major adverse CV events (MACE) 2.14% (95% CI 0.64-4.21), death 0.96% (95% CI 0.00-2.98), CV death 0.46% (95% CI 0.00-2.17), myocardial infarction (MI) 0.94% (95% CI 0.04-2.56), stent thrombosis 0.99% (95% CI 0.00-6.14) and target vessel revascularization 0% (95% CI 0.00-0.32). Thirty-day outcomes were MACE 4.79% (95% CI 1.51-9.35), mortality 3.09% (95% CI 0.00-9.69) and MI 2.25% (95% CI 0.45-4.95).ConclusionsUse of IVL during PCI of calcified left main disease is associated with a favorable procedural rates of success, with low risk of procedural complications and ischemic events.
Details
- Title: Subtitle
- Safety and Efficacy of Intravascular Lithotripsy in Calcified Left Main Coronary Artery Disease: A Systematic Review and Meta-Analysis
- Creators
- Shanmukh Sai Pavan Lingamsetty - Mamata Medical CollegeHarshith Thyagaturu - West Virginia UniversitySahib Singh - Sinai HospitalAvinashsingh Eswarsingh - East Carolina UniversityShwetha Gopal - Bassett Medical CenterDipesh Ludhwani - University of Maryland Eastern ShoreAdemola Ajibade - West Virginia UniversityVijaykumar Sekar - Lehigh Valley Health NetworkVikrant Jagadeesan - West Virginia University
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.106(1), p.336
- DOI
- 10.1002/ccd.31554
- PMID
- 40270001
- NLM abbreviation
- Catheter Cardiovasc Interv
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- The authors received no specific funding for this work.
- Language
- English
- Date published
- 04/24/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845467702771
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