Journal article
Safety and efficacy of HepaSphere 50-100 μm in the treatment of hepatocellular carcinoma
Minimally invasive therapy and allied technologies, Vol.26(4), pp.212-219
07/04/2017
DOI: 10.1080/13645706.2017.1288142
PMID: 28635404
Abstract
Aim: To evaluate the effects of HepaSphere 50-100 μm (Merit Medical) as a doxorubicin carrier and embolization agent for the treatment of hepatocellular carcinoma (HCC).
Material and methods: A prospective analysis of 18 patients recruited from a national cancer center was conducted. This analysis evaluated the efficacy and safety of HepaSphere, as expressed by the treatment response rate (measured by the modified Response Evaluation Criteria in Solid Tumors, mRECIST) and by the prevalence of treatment-related adverse events, respectively.
Results: The cohort was predominantly male, with a mean age of 69 years. The objective response rate (complete + partial response) was 53.3%. The variable most likely to be associated with objective response was Barcelona Clinic Liver Cancer (BCLC) staging. The most prevalent adverse events were nausea, vomiting and abdominal pain.
Conclusion: HepaSphere chemoembolization yielded a substantial objective response rate with an acceptable toxicity profile and should be considered an option for HCC treatment.
Details
- Title: Subtitle
- Safety and efficacy of HepaSphere 50-100 μm in the treatment of hepatocellular carcinoma
- Creators
- Charles Edouard Zurstrassen - AC Camargo HospitalLuiz Paulo De Oliveira Gireli - AC Camargo HospitalChiang Jeng Tyng - AC Camargo HospitalAlmir Galvão Vieira Bitencourt - AC Camargo HospitalMarcos Duarte Guimarães - AC Camargo HospitalPaula Nicole Vieira Barbosa - AC Camargo HospitalAline Cristine Barbosa Santos Cavalcante - AC Camargo HospitalJoão Paulo Matushita Junior - AC Camargo HospitalMauricio Kauark Amoedo - AC Camargo HospitalFelipe Jose Coimbra - AC Camargo HospitalRogério Camargo Pinheiro Alves - AC Camargo HospitalRubens Chojniak - AC Camargo Hospital
- Resource Type
- Journal article
- Publication Details
- Minimally invasive therapy and allied technologies, Vol.26(4), pp.212-219
- Publisher
- Taylor & Francis
- DOI
- 10.1080/13645706.2017.1288142
- PMID
- 28635404
- ISSN
- 1364-5706
- eISSN
- 1365-2931
- Language
- English
- Date published
- 07/04/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984697722702771
Metrics
3 Record Views