Logo image
Back
Safety and efficacy of rapidly administered (one hour) one gram of low molecular weight iron dextran (INFeD) for the treatment of iron deficient anemia
Journal article   Open access   Peer reviewed

Safety and efficacy of rapidly administered (one hour) one gram of low molecular weight iron dextran (INFeD) for the treatment of iron deficient anemia

Michael Auerbach, Jennifer A Pappadakis, Huzefa Bahrain, Sarah A Auerbach, Harold Ballard and Naomi V Dahl
American journal of hematology, Vol.86(10), pp.860-862
10/2011
DOI: 10.1002/ajh.22153
PMID: 21922526
url
https://doi.org/10.1002/ajh.22153View
Published (Version of record) Open Access

Abstract

Oral iron is a standard treatment of iron deficient anemia despite high rates of intolerance and nonadherence and may not replenish iron stores rapidly enough to meet ongoing losses [1]. Intravenous (IV) iron has advantages but remains underutilized. Whereas most formulations of IV iron require multiple doses for replacement, low molecular weight iron dextran (LMW ID) may be administered as a total dose infusion, typically over a 4- to 6-hr period [2, 3]. A 4-hr infusion for doses up to 4 g was standard in our practice until 2 years ago. However, clinical studies suggest that 1 g of IV iron is an adequate dose for many patients [3-5], and it became apparent that we were frequently infusing doses of at least 1 g in 1 hr without evidence of significant adverse events [3]. Now, our clinical practice routinely infuses 1 g of LMW ID in 250 mL normal saline over 1 hr without premedication as our standard practice. We summarize our experience with the safety and efficacy of this method of administering IV iron in unselected patients with iron deficiency.
 Adolescent Adult Aged Aged, 80 and over Anemia, Iron-Deficiency - drug therapy Female Humans Infusions, Intravenous Iron-Dextran Complex - administration & dosage Iron-Dextran Complex - adverse effects Male Middle Aged Young Adult

Details

Metrics

52 Record Views
91 Times Cited - Web of Science
Logo image