Journal article
Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
Vaccine, Vol.25(44), pp.7656-7663
2007
DOI: 10.1016/j.vaccine.2007.08.042
PMCID: PMC2243220
PMID: 17913310
Abstract
To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60
μg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15
μg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (≥4-fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers ≥1:32, ≥1:64, and ≥1:128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly.
Details
- Title: Subtitle
- Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
- Creators
- Robert B Couch - Baylor College of Medicine, One Baylor Plaza, MS: BCM280, Houston , TX 77030, United StatesPatricia Winokur - University of Iowa and VA Medical Center, 200 Hawkins Dr., Iowa City , IA 52242, United StatesRebecca Brady - Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLD 6014, Cincinnati , OH 45229-3039, United StatesRobert Belshe - Saint Louis University School of Medicine, 3635 Vista Ave., St. Louis , MO 63119, United StatesWilbur H Chen - University of Maryland School of Medicine, 685 W. Baltimore St., Suite 480, Baltimore , MD 21201, United StatesThomas R Cate - Baylor College of Medicine, One Baylor Plaza, MS: BCM280, Houston , TX 77030, United StatesBryndis Sigurdardottir - University of Iowa and VA Medical Center, 200 Hawkins Dr., Iowa City , IA 52242, United StatesAmy Hoeper - Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLD 6014, Cincinnati , OH 45229-3039, United StatesIrene L Graham - Saint Louis University School of Medicine, 3635 Vista Ave., St. Louis , MO 63119, United StatesRobert Edelman - University of Maryland School of Medicine, 685 W. Baltimore St., Suite 480, Baltimore , MD 21201, United StatesFenhua He - The EMMES Corporation, 401 N. Washington Street, Suite 700, Rockville, MD 20850, United StatesDiane Nino - Baylor College of Medicine, One Baylor Plaza, MS: BCM280, Houston , TX 77030, United StatesJose Capellan - Sanofi Pasteur, 11755 Steeles Avenue West, Toronto , Ontario , Canada M2R 3T4Frederick L Ruben - Sanofi Pasteur, Discovery Drive, Swiftwater , PA 18370, United States
- Resource Type
- Journal article
- Publication Details
- Vaccine, Vol.25(44), pp.7656-7663
- DOI
- 10.1016/j.vaccine.2007.08.042
- PMID
- 17913310
- PMCID
- PMC2243220
- NLM abbreviation
- Vaccine
- ISSN
- 0264-410X
- eISSN
- 1873-2518
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2007
- Academic Unit
- Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094669902771
Metrics
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