Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults

Rebecca C Brady; John J Treanor; Robert L Atmar; Wendy A Keitel; Robert Edelman; Wilbur H Chen; Patricia Winokur; Robert Belshe; Irene L Graham; Diana Lee Noah; Kuo Guo; Heather Hill

doi:10.1016/j.vaccine.2009.06.057

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Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults

Journal article

Open access

Peer reviewed

Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults

Rebecca C Brady, John J Treanor, Robert L Atmar, Wendy A Keitel, Robert Edelman, Wilbur H Chen, Patricia Winokur, Robert Belshe, Irene L Graham, Diana Lee Noah, …

Vaccine, Vol.27(37), pp.5091-5095

08/13/2009

DOI: 10.1016/j.vaccine.2009.06.057

PMCID: PMC2730950

PMID: 19577636

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Abstract

A total of 600 healthy adults > or =65 years were randomized to receive 2 vaccinations 1 month apart of a subvirion avian influenza A/H5N1 vaccine containing 3.75, 7.5, 15, or 45microg of hemagglutinin (HA) with or without aluminum hydroxide (AlOH). All formulations were safe. Groups given the vaccine with AlOH had more injection site discomfort. Dose-related increases in antibody responses were noted after the second vaccination. Antibody responses to the vaccine were not enhanced by AlOH at any HA dose level. A microneutralization titer > or =40 was observed in 36% and 40% of subjects who received 45microg of HA with or without AlOH, respectively.

Adjuvants, Immunologic

Humans

Vaccination

Influenza Vaccines - adverse effects

Male

Neutralization Tests

Hemagglutinin Glycoproteins, Influenza Virus - immunology

Antibodies, Viral - blood

Dose-Response Relationship, Drug

Hemagglutination Inhibition Tests

Influenza Vaccines - immunology

Influenza A Virus, H5N1 Subtype - immunology

Aluminum Hydroxide - immunology

Female

Aged

Influenza, Human - prevention & control

Influenza, Human - immunology

Details

Title: Subtitle: Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults
Creators: Rebecca C Brady - Cincinnati Children's Hospital Medical Center, OH 45229-3039, United States. rebecca.brady@cchmc.org
John J Treanor
Robert L Atmar
Wendy A Keitel
Robert Edelman
Wilbur H Chen
Patricia Winokur
Robert Belshe
Irene L Graham
Diana Lee Noah
Kuo Guo
Heather Hill - Emmes (United States)
Resource Type: Journal article
Publication Details: Vaccine, Vol.27(37), pp.5091-5095
DOI: 10.1016/j.vaccine.2009.06.057
PMID: 19577636
PMCID: PMC2730950
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Grant note: K12 RR023250 / NCRR NIH HHS N01 AI025465 / NIAID NIH HHS N01-AI-45250 / NIAID NIH HHS N01 AI045250 / NIAID NIH HHS K12RR023250 / NCRR NIH HHS N01AI25465 / NIAID NIH HHS N01 AI025460 / NIAID NIH HHS N01AI25459 / NIAID NIH HHS N01AI25461 / NIAID NIH HHS N01AI30068 / NIAID NIH HHS M01 RR016500 / NCRR NIH HHS N01AI45250 / NIAID NIH HHS M01-RR-16500 / NCRR NIH HHS N01 AI025459 / NIAID NIH HHS N01-AI-25465 / NIAID NIH HHS N01AI25460 / NIAID NIH HHS N01-AI-25461 / NIAID NIH HHS N01 AI030068 / NIAID NIH HHS N01-AI-30068 / NIAID NIH HHS N01 AI025461 / NIAID NIH HHS
Language: English
Date published: 08/13/2009
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984094598202771

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