Journal article
Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke
Regenerative medicine, Vol.6(1), pp.45-52
01/01/2011
DOI: 10.2217/RME.10.97
PMID: 21175286
Abstract
Aims: To assess the safety and feasibility of intra-arterial transplantation of autologous bone marrow mononuclear cells in patients with middle cerebral artery ischemic stroke within 90 days of symptom onset. Patients & methods: Six patients were included in the study, and they received 1-5 x 10(8) bone marrow mononuclear cell and were evaluated using blood tests, neurological and imaging examination before treatment, and 1, 3, 7, 30, 60, 90, 120 and 180 days after transplantation. Scintigraphies were carried out 2 and 24 h after the procedure to analyze the biodistribution of labeled cells. Electroencephalogram was conducted within 7 days after transplantation. Results: No patients exhibited any complication or adverse events during the procedure. There was no worsening in the neurological scales until the end of the follow-up. Conclusion: Intra-arterial bone marrow mononuclear cell transplantation is feasible and safe in patients with nonacute ischemic strokes of the middle cerebral artery. Further studies are required to evaluate the efficacy of this therapy.
Details
- Title: Subtitle
- Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke
- Creators
- Valeria Battistella - Universidade Federal do Rio de JaneiroGabriel R. de Freitas - Universidade Federal do Rio de JaneiroLea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Programa Terapia Celular, Rio De Janeiro, BrazilDaniel Mercante - Hospital Universitário Clementino Fraga FilhoBianca Gutfilen - Universidade Federal do Rio de JaneiroRegina C. S. Goldenberg - Univ Fed Rio de Janeiro, Programa Terapia Celular, Rio De Janeiro, BrazilJuliana Vieira Dias - Universidade Federal do Rio de JaneiroTais H. Kasai-Brunswick - Universidade Federal do Rio de JaneiroEduardo Wajnberg - Hospital Universitário Clementino Fraga FilhoPaulo Henrique Rosado-de-Castro - Hospital Universitário Clementino Fraga FilhoSoniza V. Alves-Leon - Universidade Federal do Rio de JaneiroRosalia Mendez-Otero - Universidade Federal do Rio de JaneiroCharles Andre - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Regenerative medicine, Vol.6(1), pp.45-52
- DOI
- 10.2217/RME.10.97
- PMID
- 21175286
- NLM abbreviation
- Regen Med
- ISSN
- 1746-0751
- eISSN
- 1746-076X
- Publisher
- Future Medicine Ltd
- Number of pages
- 8
- Grant note
- Ministry of Health 552201/2005-7 / Ministry of Science and Technology of Brazil
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Radiology
- Record Identifier
- 9985143554202771
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