Journal article
Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
Pediatric radiology, Vol.50(5), pp.646-655
05/2020
DOI: 10.1007/s00247-019-04604-0
PMCID: PMC7153994
PMID: 31980848
Abstract
Hyperpolarized helium 3 magnetic resonance imaging (
He MRI) is useful for investigating pulmonary physiology of pediatric asthma, but a detailed assessment of the safety profile of this agent has not been performed in children.
To evaluate the safety of
He MRI in children and adolescents with asthma.
This was a retrospective observational study.
He MRI was performed in 66 pediatric patients (mean age 12.9 years, range 8-18 years, 38 male, 28 female) between 2007 and 2017. Fifty-five patients received a single repeated examination and five received two repeated examinations. We assessed a total of 127
He MRI exams. Heart rate, respiratory rate and pulse oximetry measured oxygen saturation (SpO
) were recorded before, during (2 min and 5 min after gas inhalation) and 1 h after MRI. Blood pressure was obtained before and after MRI. Any subjective symptoms were also noted. Changes in vital signs were tested for significance during the exam and divided into three subject age groups (8-12 years, 13-15 years, 16-18 years) using linear mixed-effects models.
There were no serious adverse events, but three minor adverse events (2.3%; headache, dizziness and mild hypoxia) were reported. We found statistically significant increases in heart rate and SpO
after
He MRI. The youngest age group (8-12 years) had an increased heart rate and a decreased respiratory rate at 2 min and 5 min after
H inhalation, and an increased SpO
post MRI.
The use of
He MRI is safe in children and adolescents with asthma.
Details
- Title: Subtitle
- Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
- Creators
- Nanae Tsuchiya - University of Wisconsin–MadisonMark L Schiebler - University of Wisconsin–MadisonMichael D Evans - University of Wisconsin–MadisonRobert V Cadman - University of Wisconsin–MadisonRonald L Sorkness - University of Wisconsin–MadisonRobert F Lemanske Jr - University of Wisconsin–MadisonDaniel J Jackson - University of Wisconsin–MadisonNizar N Jarjour - University of Wisconsin–MadisonLoren C Denlinger - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Pediatric radiology, Vol.50(5), pp.646-655
- DOI
- 10.1007/s00247-019-04604-0
- PMID
- 31980848
- PMCID
- PMC7153994
- NLM abbreviation
- Pediatr Radiol
- ISSN
- 0301-0449
- eISSN
- 1432-1998
- Grant note
- R01 HL126771 / NHLBI NIH HHS U10 HL109168 / NHLBI NIH HHS R01 HL126771 / NIH HHS P01 HL070831 / NHLBI NIH HHS UL1 TR000427 / NCATS NIH HHS S10 OD016394 / NIH HHS P01 HL070831 / NIH HHS U10 HL109168 / NIH HHS UL1 TR002373 / NCATS NIH HHS
- Language
- English
- Date published
- 05/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274953002771
Metrics
20 Record Views