Journal article
Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres
Neuroscience letters, Vol.747, pp.135705-135705
03/16/2021
DOI: 10.1016/j.neulet.2021.135705
PMCID: PMC7957321
PMID: 33548408
Abstract
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•Spontaneous firing rates were recorded from single auditory fibres in vivo.•Salicylate was injected at 350 mg/kg by the subcutaneous route.•Median firing rate decreased by 32 spikes/s in nerve fibres after salicylate injection.•The high spontaneous rate fibres (type 1A) showed the main reduction.
Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in at least one type of afferent auditory nerve fibre in anaesthetised guinea pigs. In control animals there was a bimodal distribution of spontaneous rates, but the position of the second mode was different depending upon whether the fibres responded best to high (> 4 kHz) or low (≤4 kHz) frequency tonal stimulation. The simplest and most reliable way of inducing tinnitus in experimental animals is to administer a high dose of sodium salicylate. The distribution of the spontaneous firing rates was different when salicylate (350 mg/kg) was administered, even when the sample was matched for the distribution of characteristic frequencies in the control population. The proportion of medium spontaneous rate fibres (MSR, 1≤ spikes/s ≤20) increased while the proportion of the highest, high spontaneous firing rate fibres (HSR, > 80 spikes/s) decreased following salicylate. The median rate fell from 64.7 spikes/s (control) to 35.4 spikes/s (salicylate); a highly significant change (Kruskal-Wallis test p < 0.001). When the changes were compared with various models of statistical probability, the most accurate model was one where most HSR fibres decreased their firing rate by 32 spikes/s. Thus, we have shown a reduction in the firing rate of HSR fibres that may be related to tinnitus.
Details
- Title: Subtitle
- Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres
- Creators
- Mark N. Wallace - MRC Institute of Hearing ResearchChristian J. Sumner - MRC Institute of Hearing ResearchJoel I. Berger - MRC Institute of Hearing ResearchPeter A. McNaughton - King's College LondonAlan R. Palmer - MRC Institute of Hearing Research
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.747, pp.135705-135705
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.neulet.2021.135705
- PMID
- 33548408
- PMCID
- PMC7957321
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Grant note
- DOI: 10.13039/501100000265, name: Medical Research Council, award: MC_U135097127, TRIH 2018
- Language
- English
- Date published
- 03/16/2021
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984618651302771
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