Salmonella enterica Serovar Typhimurium Requires Nonsterol Precursors of the Cholesterol Biosynthetic Pathway for Intracellular Proliferation

Drew M Catron; Yvonne Lange; Jayme Borensztajn; Matthew D Sylvester; Bradley D Jones; Kasturi Haldar

doi:10.1128/IAI.72.2.1036-1042.2004

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Salmonella enterica Serovar Typhimurium Requires Nonsterol Precursors of the Cholesterol Biosynthetic Pathway for Intracellular Proliferation

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Salmonella enterica Serovar Typhimurium Requires Nonsterol Precursors of the Cholesterol Biosynthetic Pathway for Intracellular Proliferation

Drew M Catron, Yvonne Lange, Jayme Borensztajn, Matthew D Sylvester, Bradley D Jones and Kasturi Haldar

Infection and immunity, Vol.72(2), pp.1036-1042

02/2004

DOI: 10.1128/IAI.72.2.1036-1042.2004

PMCID: PMC321618

PMID: 14742551

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Abstract

We have previously shown that Salmonella enterica serovar Typhimurium infection perturbs the host cholesterol biosynthetic pathway. Here we show that inhibiting the first step of this pathway (3-hydroxy-3-methylglutaryl coenzyme A reductase) reduces the growth of intracellular S. enterica serovar Typhimurium and has no effect on extracellular bacterial growth. Selectively inhibiting synthesis of downstream sterol components has no effect on infection, suggesting that the effect of statins on host nonsterol intermediates is detrimental to bacterial growth. Furthermore, statins also reduce bacterial proliferation in the S. enterica serovar Typhimurium mouse model. This suggests that blocking the production of nonsterol precursors in the host cell can be used to reduce infection.

Molecular Pathogenesis

Details

Title: Subtitle: Salmonella enterica Serovar Typhimurium Requires Nonsterol Precursors of the Cholesterol Biosynthetic Pathway for Intracellular Proliferation
Creators: Drew M Catron - Departments of Pathology and Microbiology-Immunology
Yvonne Lange - Departments of Pathology and Microbiology-Immunology
Jayme Borensztajn - Departments of Pathology and Microbiology-Immunology
Matthew D Sylvester - Departments of Pathology and Microbiology-Immunology
Bradley D Jones - Departments of Pathology and Microbiology-Immunology
Kasturi Haldar - Departments of Pathology and Microbiology-Immunology
Resource Type: Journal article
Publication Details: Infection and immunity, Vol.72(2), pp.1036-1042
DOI: 10.1128/IAI.72.2.1036-1042.2004
PMID: 14742551
PMCID: PMC321618
NLM abbreviation: Infect Immun
ISSN: 0019-9567
eISSN: 1098-5522
Publisher: American Society for Microbiology
Language: English
Date published: 02/2004
Academic Unit: Microbiology and Immunology
Record Identifier: 9984083825902771

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