Journal article
Salt appetite: interaction of forebrain angiotensinergic and hindbrain serotonergic mechanisms
Brain research, Vol.801(1), pp.29-35
1998
DOI: 10.1016/S0006-8993(98)00530-7
PMID: 9729254
Abstract
Methysergide injected bilaterally into the lateral parabrachial nucleus (LPBN) increases NaCl intake in several models of renin-dependent salt appetite. The present study investigated the role of angiotensin Type 1 (AT
1) receptors in the subfornical organ (SFO) on this effect. The intake of 0.3 M NaCl and water was induced by combined administration of the diuretic, furosemide (FURO), and the angiotensin-converting enzyme inhibitor, captopril (CAP). Pretreatment of the SFO with an AT
1 receptor antagonist, losartan (1 μg/200 nl), reduced water intake but not 0.3 M NaCl intake induced by subcutaneous FURO+CAP. Methysergide (4 μg/200 nl) injected bilaterally into the LPBN increased 0.3 M NaCl intake after FURO+CAP. Losartan injected into the SFO prevented the additional 0.3 M NaCl intake caused by LPBN methysergide injections. These results indicate that AT
1 receptors located in the SFO may have a role in mediating an enhanced sodium intake produced by methysergide treatment.
Details
- Title: Subtitle
- Salt appetite: interaction of forebrain angiotensinergic and hindbrain serotonergic mechanisms
- Creators
- Jose Vanderlei Menani - Department of Physiology, School of Dentistry, Paulista State University, Araraquara, SP 14801-903, BrazilDebora S.A Colombari - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USATerry G Beltz - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USARobert L Thunhorst - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USAAlan Kim Johnson - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.801(1), pp.29-35
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(98)00530-7
- PMID
- 9729254
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1998
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213261102771
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