Journal article
Salvage lung SBRT may be a curative option after lobectomy
Reports of practical oncology and radiotherapy, Vol.30(1), pp.27-33
01/01/2025
DOI: 10.5603/rpor.104385
PMCID: PMC11999021
PMID: 40242425
Abstract
Background: This study intends to analyze the feasibility and the outcomes of stereotactic body radiotherapy (SBRT) as a salvage treatment for lung cancer after primary surgery and compare them with the results of SBRT as the first treatment option. Materials and methods: Retrospective analysis of early-stage non-small cell lung cancer (NSCLC) treated with SBRT, either as a primary treatment or as salvage treatment after primary surgery. Results: From January 2017 to January 2022, 68 patients were analyzed. 80% were 65 years-old or above. Seven (10%) underwent SBRT as a salvage treatment after primary surgery. Most lesions treated with primary SBRT were peripheral (n = 33; 54.1%), opposed to the salvage group, where 71.4% were central lesions (n = 5). Patients who had previous surgery presented with lower forced expiratory volume in 1 second (FEV1) (p = 0.006). Median time between surgery and salvage SBRT was 35.4 months. Median follow-up was 29.3 months; median overall survival (OS) at 2 years and 3 years was, respectively, 73.5% and 67.6% (median 52.5 months), with no difference between groups. Median local, regional, and distant progression free survivals were not reached. Local control was 94.1% at 2 years and 92.6% at 3 years. Only 5 (8.2%) patients presented late grade 3-4 pneumonitis, and one, grade 5 (fatal), all in the primary SBRT group. Conclusion: SBRT as salvage after primary surgery is feasible and seems to be safe. Outcomes are expected to be equivalent to those of the patients submitted to primary SBRT.
Details
- Title: Subtitle
- Salvage lung SBRT may be a curative option after lobectomy
- Creators
- Geovanne Pedro Mauro - Universidade de São PauloMaria Luiza Alves Jose Ferioli Pereira - Universidade de São PauloMauricio Jose de Oliveira Costa - Universidade de São PauloHeloisa A. Carvalho - Universidade de São Paulo
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.30(1), pp.27-33
- DOI
- 10.5603/rpor.104385
- PMID
- 40242425
- PMCID
- PMC11999021
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Via Medica
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2025
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914147202771
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