Journal article
Same‐Day Repeatability and 28‐Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi‐Site Trial
Journal of magnetic resonance imaging, Vol.61(4), pp.1664-1674
04/2025
DOI: 10.1002/jmri.29605
PMCID: PMC11896927
PMID: 39257323
Abstract
Background MRI with xenon‐129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi‐site study. Purpose To determine the same‐day repeatability and 28‐day reproducibility of Xe MRI in children with CF. Study Type Four‐center prospective, longitudinal. Population Thirty‐eight children (18 females, 47%), median interquartile range (IQR) age 12 (9–14) years old, with mild CF (forced expiratory volume in 1 second (FEV 1 ) ≥85% predicted). Field Strength/Sequence 3‐T, two‐dimensional (2D) gradient‐echo (GRE) sequence. Assessment Xe MRI, FEV 1 , and nitrogen multiple‐breath wash‐out for lung‐clearance index (LCI 2.5 ) were performed. To assess same‐day reproducibility, Xe MRI was performed twice within the first visit, and procedures were repeated at 28 days. Xe hypoventilation was quantified using ventilation‐defect percentage (VDP) and reader‐defect volume (RDV). For VDP, hypoventilated voxels from segmented images were identified using a threshold of <60% mean whole‐lung signal and expressed as a percentage of the lung volume. For RDV, hypoventilation was identified by two trained readers and expressed as a percentage. Statistical Tests Inter‐site comparisons were conducted using Kruskal–Wallis nonparametric tests with Dunn's multiple‐comparisons tests. Differences for individuals were assessed using Wilcoxon matched‐pairs tests. Bland–Altman tests were used to evaluate same‐day repeatability, 28‐day reproducibility, and inter‐reader agreement. A P ‐value ≤0.05 was considered significant. Results Median FEV 1 %‐predicted was 96.8% (86%–106%), and median LCI 2.5 was 6.6 (6.3–7.4). Xe MRI had high same‐day reproducibility (mean VDP difference 0.12%, 95% limits of agreement [−3.2, 3.4]; mean RDV difference 0.42% [−2.5, 3.3]). At 28 days, 26/31 participants (84%) fell within the same‐day 95% limits of agreement. Data Conclusion Xe MRI may offer excellent same‐day and short‐term reproducibility. Evidence Level 2 Technical Efficacy Stage 2
Details
- Title: Subtitle
- Same‐Day Repeatability and 28‐Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi‐Site Trial
- Creators
- Laura L. Walkup - Cincinnati Children's Hospital Medical CenterDavid J. Roach - Cincinnati Children's Hospital Medical CenterJoseph W. Plummer - Cincinnati Children's Hospital Medical CenterMatthew M. Willmering - Cincinnati Children's Hospital Medical CenterBrandon Zanette - Hospital for Sick ChildrenGiles Santyr - University of TorontoSean B. Fain - University of IowaMichael J. Rock - University of Wisconsin–MadisonJaime Mata - University of VirginiaDeborah Froh - University of VirginiaSanja Stanojevic - Dalhousie UniversityZackary I. Cleveland - Cincinnati Children's Hospital Medical CenterFelix Ratjen - Hospital for Sick ChildrenJason C. Woods - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.61(4), pp.1664-1674
- DOI
- 10.1002/jmri.29605
- PMID
- 39257323
- PMCID
- PMC11896927
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Publisher
- WILEY
- Grant note
- Cystic Fibrosis Foundation: WOODS19A0 University of Cincinnati Center for Clinical and Translational Science and Training (National Institutes of Health Clinical and Translational Science Award): UL1TR001425
The authors would like to acknowledge the HyPOINT study-team members at Cincinnati Children's Hospital (Kelly Thornton, Carrie Stevens, Megan Schmitt, and Carter McMaster); Hospital for Sick Children Toronto (Aviva West, Jacky Au, Sharon Braganza, Daniel Li, Samal Munidasa, and Yonni Friedlander); University of Virginia (Roselove Asare and Rene Herrera); and University of Wisconsin-Madison for their contributions to this study. Data from this study were presented in part at the American Thoracic Society ATS 2021 and 2022 meetings and the North American Cystic Fibrosis Conference (NACFC) 2021. This work was supported by the Cystic Fibrosis Foundation (WOODS19A0) and University of Cincinnati Center for Clinical and Translational Science and Training (National Institutes of Health Clinical and Translational Science Award UL1TR001425).
- Language
- English
- Electronic publication date
- 09/11/2024
- Date published
- 04/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984704623702771
Metrics
13 Record Views