Journal article
Samhd1 knockout mice: modeling retrovirus restriction in vivo
Retrovirology, Vol.10(1), pp.142-142
11/20/2013
DOI: 10.1186/1742-4690-10-142
PMCID: PMC3842632
PMID: 24257155
Abstract
The host dNTP hydrolase SAMHD1 acts as a viral restriction factor to inhibit the replication of several retroviruses and DNA viruses in non-cycling human immune cells. However, understanding the physiological role of mammalian SAMHD1 has been elusive due to the lack of an animal model. Two recent studies reported the generation of
samhd1
knockout mouse models for investigating the restriction of HIV-1 vectors and endogenous retroviruses
in vivo
. Both studies suggest that SAMHD1 is important for regulating the intracellular dNTP pool and the intrinsic immunity against retroviral infection, despite different outcomes of HIV-1 vector transduction in these mouse models. Here I discuss the significance of these new findings and the future directions in studying SAMHD1-mediated retroviral restriction.
Details
- Title: Subtitle
- Samhd1 knockout mice: modeling retrovirus restriction in vivo
- Creators
- Li Wu - Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA
- Resource Type
- Journal article
- Publication Details
- Retrovirology, Vol.10(1), pp.142-142
- DOI
- 10.1186/1742-4690-10-142
- PMID
- 24257155
- PMCID
- PMC3842632
- NLM abbreviation
- Retrovirology
- ISSN
- 1742-4690
- eISSN
- 1742-4690
- Publisher
- BioMed Central
- Language
- English
- Date published
- 11/20/2013
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002388302771
Metrics
31 Record Views