Sarcolemmal ATP-sensitive K+ channels control energy expenditure determining body weight

Alexey E Alekseev; Santiago Reyes; Satsuki Yamada; Denice M Hodgson-Zingman; Srinivasan Sattiraju; Zhiyong Zhu; Ana Sierra; Marina Gerbin; William A Coetzee; David J Goldhamer; Andre Terzic; Leonid V Zingman

doi:10.1016/j.cmet.2009.11.009

Back

Sarcolemmal ATP-sensitive K+ channels control energy expenditure determining body weight

Journal article

Open access

Peer reviewed

Sarcolemmal ATP-sensitive K+ channels control energy expenditure determining body weight

Alexey E Alekseev, Santiago Reyes, Satsuki Yamada, Denice M Hodgson-Zingman, Srinivasan Sattiraju, Zhiyong Zhu, Ana Sierra, Marina Gerbin, William A Coetzee, David J Goldhamer, …

Cell metabolism, Vol.11(1), pp.58-69

01/2010

DOI: 10.1016/j.cmet.2009.11.009

PMCID: PMC2849280

PMID: 20074528

Files and links (1)

url

https://doi.org/10.1016/j.cmet.2009.11.009View

Published (Version of record) Open Access

Abstract

Metabolic processes that regulate muscle energy use are major determinants of bodily energy balance. Here we find that sarcolemmal ATP-sensitive K + (K ATP ) channels, which couple membrane excitability with cellular metabolic pathways, set muscle energy expenditure under physiological stimuli. Disruption of K ATP channel function provoked, in conditions of unaltered locomotor activity and blood substrate availability, an extra energy cost of cardiac and skeletal muscle performance. Inefficient fuel metabolism in K ATP channel-deficient striated muscles reduced glycogen and fat body depots promoting a lean phenotype. The propensity to lesser body weight imposed by K ATP channel deficit persisted under a high-fat diet, yet obesity restriction was achieved at the cost of compromised physical endurance. Thus, sarcolemmal K ATP channels govern muscle energy economy, and their down-regulation in a tissue-specific manner could present an anti-obesity strategy by rendering muscle increasingly thermogenic at rest and less fuel efficient during exercise.

Details

Title: Subtitle: Sarcolemmal ATP-sensitive K+ channels control energy expenditure determining body weight
Creators: Alexey E Alekseev - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Santiago Reyes - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Satsuki Yamada - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Denice M Hodgson-Zingman - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Srinivasan Sattiraju - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Zhiyong Zhu - Department of Internal Medicine, University of Iowa, Carver College of Medicine, 285 Newton Rd., CBRB2296, Iowa City, Iowa 52242 USA
Ana Sierra - Department of Internal Medicine, University of Iowa, Carver College of Medicine, 285 Newton Rd., CBRB2296, Iowa City, Iowa 52242 USA
Marina Gerbin - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
William A Coetzee - Department of Pediatrics, NYU School of Medicine, 560 First Avenue TCH-521, New York, New York 10016, USA
David J Goldhamer - The Center for Regenerative Biology, Department of Molecular and Cell Biology, Advanced Technology Laboratory, University of Connecticut, 1392 Storrs Road Unit 4243, Storrs, Connecticut 06269, USA
Andre Terzic - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Leonid V Zingman - Marriott Heart Diseases Research Program, Division of Cardiovascular Diseases, Department of Medicine, Department of Molecular Pharmacology and Experimental Therapeutics and Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Resource Type: Journal article
Publication Details: Cell metabolism, Vol.11(1), pp.58-69
DOI: 10.1016/j.cmet.2009.11.009
PMID: 20074528
PMCID: PMC2849280
ISSN: 1550-4131
eISSN: 1932-7420
Language: English
Date published: 01/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094372102771

Metrics

19 Record Views

59 Times Cited - Web of Science

See more details