Journal article
Sarcopenia is associated with increased mortality but not complications following resection and reconstruction of sarcoma of the extremities
Journal of surgical oncology, Vol.121(8), pp.1241-1248
06/15/2020
DOI: 10.1002/jso.25898
PMID: 32162343
Abstract
Background and Objectives
Evidence regarding the impact of sarcopenia on operative outcomes in patients with sarcoma is lacking. We evaluated the relationship between sarcopenia and postoperative complications or mortality among patients undergoing tumor excision and reconstruction.
Methods
We retrospectively reviewed 145 patients treated with tumor excision and limb reconstruction for sarcoma of the extremities. Sarcopenia was defined as psoas index (PI) < 5.45 cm2/m2 for men and <3.85 cm2/m2 for women from preoperative axial CT. Regression analyses were used to assess the association between postoperative complications or mortality with PI, age, gender, race, body mass index, tumor histology, grade, depth, location, size, and neoadjuvant/adjuvant therapy.
Results
There were 101 soft tissue tumors and 44 primary bone tumors. Sarcopenia was present in 38 patients (26%). Sarcopenic patients were older (median age: 72 vs 59 years, P = .0010) and had larger tumors (86.5%, >5 cm vs 77.7%, P = .023). Seventy‐three patients experienced complications (51%) and 18 patients died within 1 year. Sarcopenia and metastatic disease were associated with increased 12‐month mortality (hazard ratio [HR] = 6.68, P < .001; HR: 8.51, P < .001, respectively) but not complications (HR 1.45, P = .155, odds ratio, 1.32, P = .426, respectively).
Conclusions
Sarcopenia and metastatic disease were independently associated with postoperative mortality but no complications following surgery.
Details
- Title: Subtitle
- Sarcopenia is associated with increased mortality but not complications following resection and reconstruction of sarcoma of the extremities
- Creators
- Nathan R. Hendrickson - University of IowaZachary Mayo - University of IowaAlan Shamrock - University of IowaKyle Kesler - University of IowaNatalie Glass - University of IowaPeter Nau - University of IowaBenjamin J. Miller - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of surgical oncology, Vol.121(8), pp.1241-1248
- DOI
- 10.1002/jso.25898
- PMID
- 32162343
- ISSN
- 0022-4790
- eISSN
- 1096-9098
- Number of pages
- 8
- Language
- English
- Date published
- 06/15/2020
- Academic Unit
- Orthopedics and Rehabilitation; Surgery
- Record Identifier
- 9984304711102771
Metrics
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