Journal article
Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom
Proceedings of SPIE, the international society for optical engineering, Vol.12031, pp.120313R-120313R-8
01/01/2022
DOI: 10.1117/12.2613212
PMCID: PMC9087304
PMID: 35547178
Abstract
Traditional methods of quantitative analysis of CT images typically involve working with patient data, which is often expensive and limited in terms of ground truth. To counter these restrictions, quantitative assessments can instead be made through Virtual Imaging Trials (VITs) which simulate the CT imaging process. This study sought to validate DukeSim (a scanner-specific CT simulator) utilizing clinically relevant biomarkers for a customized anthropomorphic chest phantom. The physical phantom was imaged utilizing two commercial CT scanners (Siemens Somatom Force and Definition Flash) with varying imaging parameters. A computational version of the phantom was simulated utilizing DukeSim for each corresponding real acquisition. Biomarkers were computed and compared between the real and virtually acquired CT images to assess the validity of DukeSim. The simulated images closely matched the real images both qualitatively and quantitatively, with the average biomarker percent difference of 3.84% (range 0.19% to 18.27%). Results showed that DukeSim is reasonably well validated across various patient imaging conditions and scanners, which indicates the utility of DukeSim for further VIT studies where real patient data may not be feasible.
Details
- Title: Subtitle
- Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom
- Creators
- Sachin S. Shankar - Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Department of Electrical and Computer Engineering, Duke University Department of Radiology, University of Iowa Department of Biomedical Engineering, University of IowaGiavanna L. Jadick - Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Department of Electrical and Computer Engineering, Duke University Department of Radiology, University of Iowa Department of Biomedical Engineering, University of IowaEric A. Hoffman - University of IowaJarron Atha - Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Department of Electrical and Computer Engineering, Duke University Department of Radiology, University of Iowa Department of Biomedical Engineering, University of IowaJessica C. Sieren - University of IowaEhsan Samei - Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Department of Electrical and Computer Engineering, Duke University Department of Radiology, University of Iowa Department of Biomedical Engineering, University of IowaEhsan Abadi - Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Department of Electrical and Computer Engineering, Duke University Department of Radiology, University of Iowa Department of Biomedical Engineering, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Proceedings of SPIE, the international society for optical engineering, Vol.12031, pp.120313R-120313R-8
- DOI
- 10.1117/12.2613212
- PMID
- 35547178
- PMCID
- PMC9087304
- NLM abbreviation
- Proc SPIE Int Soc Opt Eng
- eISBN
- 1510649387; 9781510649385
- ISSN
- 0277-786X
- eISSN
- 1996-756X
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318781902771
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