Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT

Mark J Kupersmith; Randy Kardon; Mary Durbin; Melissa Horne; Julia Shulman

doi:10.1167/iovs.11-9339

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Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT

Journal article

Open access

Peer reviewed

Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT

Mark J Kupersmith, Randy Kardon, Mary Durbin, Melissa Horne and Julia Shulman

Investigative ophthalmology & visual science, Vol.53(4), pp.1962-1970

04/18/2012

DOI: 10.1167/iovs.11-9339

PMCID: PMC3995564

PMID: 22410562

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https://doi.org/10.1167/iovs.11-9339View

Published (Version of record) Open Access

Abstract

Optical coherence tomography (OCT) shows retinal nerve fiber layer (RNFL) thickening in optic nerve head (ONH) swelling, but does not provide information on acute axonal disruption. It was hypothesized that scanning laser polarimetry (SLP) compared with OCT might reveal the status of axon integrity and visual prognosis in acute RNFL swelling. Threshold perimetry, OCT, and SLP were used to prospectively study eyes with papilledema (24), optic neuritis (14), nonarteritic anterior ischemic optic neuropathy (NAION) (21), and ONH swelling (average RNFL value by OCT was above the 95th percentile of controls at presentation). Regional RNFL was judged reduced if the quadrant measurement was below the fifth percentile of controls. At presentation, average RNFL by OCT was similar for eyes with papilledema and NAION (P = 0.97), and reduced for optic neuritis. Average RNFL by SLP was slightly increased for papilledema and optic neuritis, and reduced for NAION (P = 0.02) eyes. The RNFL by SLP was reduced in at least one quadrant in 1 eye with papilledema, 1 eye with optic neuritis, and in 13 eyes with NAION. In NAION eyes, quadrants with reduced SLP had corresponding visual field loss that did not recover. By one month, eyes with NAION showed RNFL thinning by OCT (7/17 eyes) and by SLP (14/16 eyes) in contrast to optic neuritis (by OCT, 0/12, P = 0.006; and by SLP, 1/12, P = 0.0004). OCT and SLP revealed different aspects of RNFL changes associated with ONH swelling. OCT revealed thickening due to edema. SLP revealed a decrease in retardance in eyes with axonal injury associated with visual field loss, which is unlikely to recover.

Reproducibility of Results

Follow-Up Studies

Humans

Middle Aged

Papilledema - pathology

Male

Tomography, Optical Coherence - methods

Retinal Ganglion Cells - pathology

Young Adult

Optic Neuritis - etiology

Adolescent

Papilledema - complications

Aged, 80 and over

Adult

Female

Scanning Laser Polarimetry - methods

Aged

Optic Neuritis - pathology

Optic Disk - pathology

Details

Title: Subtitle: Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT
Creators: Mark J Kupersmith - New York Eye and Ear Infirmary and INN at Roosevelt Hospital, New York, New York 10019, USA. mkuper@chpnet.org
Randy Kardon
Mary Durbin
Melissa Horne
Julia Shulman
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.53(4), pp.1962-1970
DOI: 10.1167/iovs.11-9339
PMID: 22410562
PMCID: PMC3995564
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: U10 EY017281 / NEI NIH HHS 3U10EY017281-01A1S1 / NEI NIH HHS
Language: English
Date published: 04/18/2012
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980091902771

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