Journal article
Schedule-dependent efficacy of idarubicin (Ida) and doxorubicin (Dox)
Leukemia, Vol.8(8), pp.1401-1405
08/01/1994
PMID: 8057680
Abstract
Schedule dependency of idarubicin (Ida) and doxorubicin (Dox) toxicity was investigated in vitro using the K562 human leukemia cell line. For Dox, repeated exposure to the IC30 (d x 3) resulted in comparable survival as single exposure to the total accumulative dose (20%). For Ida, repeated exposure to the IC30 (d x 3) decreased survival to 5%, while single exposure to the total accumulative dose reduced survival only to 20%. Total cellular accumulation of Dox was independent of schedule of exposure, while for Ida, repeated exposure resulted in a significantly higher drug accumulation compared to the single exposure to the accumulative dose. The data indicate that the schedule-dependent differences in cytotoxicity for the two compounds can be accounted for almost exclusively by an increased cellular uptake and retention of Ida with repeated drug exposure.
Details
- Title: Subtitle
- Schedule-dependent efficacy of idarubicin (Ida) and doxorubicin (Dox)
- Creators
- H MindermanM D BuscagliaY M Rustum
- Resource Type
- Journal article
- Publication Details
- Leukemia, Vol.8(8), pp.1401-1405
- PMID
- 8057680
- ISSN
- 0887-6924
- eISSN
- 1476-5551
- Language
- English
- Date published
- 08/01/1994
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359856302771
Metrics
18 Record Views