Schizo-affective disorders: bipolar-unipolar subtyping: Natural history variables: a discriminant analysis approach

M.M Van Eerdewegh; P Van Eerdewegh; W Coryell; P.J Clayton; J Endicott; J Koepke; N Rochberg

doi:10.1016/0165-0327(87)90031-0

Back

Schizo-affective disorders: bipolar-unipolar subtyping: Natural history variables: a discriminant analysis approach

Journal article

Peer reviewed

Schizo-affective disorders: bipolar-unipolar subtyping: Natural history variables: a discriminant analysis approach

M.M Van Eerdewegh, P Van Eerdewegh, W Coryell, P.J Clayton, J Endicott, J Koepke and N Rochberg

Journal of affective disorders, Vol.12(3), pp.223-232

1987

DOI: 10.1016/0165-0327(87)90031-0

PMID: 2956307

View Online

Abstract

In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH Collaborative Study on the Psychobiology of Depression Clinical section: the schizo-bipolar (SBP, n = 45), the schizo-unipolar (SUP, n = 30), the bipolar I (BP, n = 159) and the primary unipolar depressed (UP, n = 387) defined by Research Diagnostic Criteria. Two dimensions were identified among the four groups of ‘affective’ patients: the ‘bipolar’ and the ‘schizophrenic’ dimensions. Theyprovided highly significant discrimination among the means of the four groups but were not very accurate in predicting group membership. The ‘bipolar’ dimension separates the UP from the BP and SBP, the SUP taking some intermediate value. The ‘schizophrenic’ dimension separates the BP and UP from the SUP, the SBP being intermediate. The two groups with the most similarities were the SBP and BP. The group with the most heterogeneity was the SUP, sharing similarities with the UP and SBP mostly. These conclusions are supported by results of familial aggregation on the same group of patients.

Schizo-affective

Bipolar

Schizo-depression

Unipolar

Discriminant analysis

DSM-III

Schizo-mania

Details

Title: Subtitle: Schizo-affective disorders: bipolar-unipolar subtyping: Natural history variables: a discriminant analysis approach
Creators: M.M Van Eerdewegh - Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA
P Van Eerdewegh - Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA
W Coryell - University of Iowa School of Medicine, Department of Psychiatry, Iowa City, IA, USA
P.J Clayton - University of Minnesota Medical School, Department of Psychiatry, Minneapolis, MN, USA
J Endicott - New York State Psychiatric Institute, New York, NY, U.S.A
J Koepke - Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA
N Rochberg - Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.12(3), pp.223-232
DOI: 10.1016/0165-0327(87)90031-0
PMID: 2956307
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 1987
Academic Unit: Psychiatry
Record Identifier: 9984003483502771

Metrics

18 Record Views

6 Times Cited - Web of Science