Journal article
Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
Proceedings of the National Academy of Sciences - PNAS, Vol.93(18), pp.9985-9990
09/03/1996
DOI: 10.1073/pnas.93.18.9985
PMCID: PMC38542
PMID: 8790444
Abstract
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental activities. Working interactively with the prefrontal cortex, the cerebellum may play a role in coordinating both motor and cognitive performance. This positron-emission tomography study suggests the presence of a prefrontal-thalamic-cerebellar network that is activated when normal subjects recall complex narrative material, but is dysfunctional in schizophrenic patients when they perform the same task. These results support a role for the cerebellum in cognitive functions and suggest that patients with schizophrenia may suffer from a "cognitive dysmetria" due to dysfunctional prefrontal-thalamic-cerebellar circuitry.
Details
- Title: Subtitle
- Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
- Creators
- N C Andreasen - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAD S O'Leary - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAT Cizadlo - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAS Arndt - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAK Rezai - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAL L Ponto - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAG L Watkins - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USAR D Hichwa - Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.93(18), pp.9985-9990
- DOI
- 10.1073/pnas.93.18.9985
- PMID
- 8790444
- PMCID
- PMC38542
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 09/03/1996
- Academic Unit
- Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984003988402771
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