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Sclerotiamide:  A New Member of the Paraherquamide Class with Potent Antiinsectan Activity from the Sclerotia of Aspergillus sclerotiorum
Journal article   Peer reviewed

Sclerotiamide:  A New Member of the Paraherquamide Class with Potent Antiinsectan Activity from the Sclerotia of Aspergillus sclerotiorum

Authrine C Whyte, James B Gloer, Donald T Wicklow and Patrick F Dowd
Journal of natural products (Washington, D.C.), Vol.59(11), pp.1093-1095
11/22/1996
DOI: 10.1021/np960607m
PMID: 8946752

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Abstract

Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C- NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.

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