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Sclerotigenin:  A New Antiinsectan Benzodiazepine from the Sclerotia of Penicillium sclerotigenum
Journal article   Peer reviewed

Sclerotigenin:  A New Antiinsectan Benzodiazepine from the Sclerotia of Penicillium sclerotigenum

Biren K Joshi, James B Gloer, Donald T Wicklow and Patrick F Dowd
Journal of natural products (Washington, D.C.), Vol.62(4), pp.650-652
04/23/1999
DOI: 10.1021/np980511n
PMID: 10217735

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Abstract

A new benzodiazepine, sclerotigenin (1), was isolated from organic extracts of the sclerotia of Penicillium sclerotigenum (NRRL 3461) along with two known griseofulvin analogues. The structure of 1 was determined primarily by analysis of 1H NMR, 13C NMR, HMQC, and HMBC data. Compound 1 was the major component of the CH2Cl2 extract of P. sclerotigenum sclerotia and is responsible for most of the antiinsectan activity of the extract against the crop pest Helicoverpa zea.

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