Journal article
Score tests for epistasis models on quantitative traits using general pedigree data
Genetic epidemiology, Vol.25(4), pp.314-326
12/2003
DOI: 10.1002/gepi.10266
PMID: 14639701
Abstract
Efficient score tests for a two-locus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalency to their respective likelihood ratio tests and efficiency in computation. The finite-sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed.
Details
- Title: Subtitle
- Score tests for epistasis models on quantitative traits using general pedigree data
- Creators
- Kai Wang - Division of Statistical Genetics, Departments of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA. kai-wang@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Genetic epidemiology, Vol.25(4), pp.314-326
- Publisher
- United States
- DOI
- 10.1002/gepi.10266
- PMID
- 14639701
- ISSN
- 0741-0395
- eISSN
- 1098-2272
- Grant note
- R01-52841 / PHS HHS
- Language
- English
- Date published
- 12/2003
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997352602771
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