Scout-view assisted interior micro-CT

Kriti Sen Sharma; Christian Holzner; Drago M Vasilescu; Xin Jin; Shree Narayanan; Masoud Agah; Eric A Hoffman; Hengyong Yu; Ge Wang

doi:10.1088/0031-9155/58/12/4297

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Journal article

Peer reviewed

Scout-view assisted interior micro-CT

Kriti Sen Sharma, Christian Holzner, Drago M Vasilescu, Xin Jin, Shree Narayanan, Masoud Agah, Eric A Hoffman, Hengyong Yu and Ge Wang

Physics in medicine & biology, Vol.58(12), pp.4297-4314

06/21/2013

DOI: 10.1088/0031-9155/58/12/4297

PMCID: PMC3732817

PMID: 23732478

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Abstract

Micro computed tomography (micro-CT) is a widely-used imaging technique. A challenge of micro-CT is to quantitatively reconstruct a sample larger than the field-of-view (FOV) of the detector. This scenario is characterized by truncated projections and associated image artifacts. However, for such truncated scans, a low resolution scout scan with an increased FOV is frequently acquired so as to position the sample properly. This study shows that the otherwise discarded scout scans can provide sufficient additional information to uniquely and stably reconstruct the interior region of interest. Two interior reconstruction methods are designed to utilize the multi-resolution data without significant computational overhead. While most previous studies used numerically truncated global projections as interior data, this study uses truly hybrid scans where global and interior scans were carried out at different resolutions. Additionally, owing to the lack of standard interior micro-CT phantoms, we designed and fabricated novel interior micro-CT phantoms for this study to provide means of validation for our algorithms. Finally, two characteristic samples from separate studies were scanned to show the effect of our reconstructions. The presented methods show significant improvements over existing reconstruction algorithms.

compressed sensing

interior tomography

truncation artifact

computed tomography (CT)

multi-resolution acquisition

scout-view

Details

Title: Subtitle: Scout-view assisted interior micro-CT
Creators: Kriti Sen Sharma - Department of Electrical and Computer Engineering , Virginia Tech, Blacksburg, VA 24061, USA
Christian Holzner - Xradia Inc., Pleasanton , CA 94588, USA
Drago M Vasilescu - University of British Columbia Department of Pathology, Vancouver, V6T 1Z4, Canada
Xin Jin - Tsinghua University Department of Engineering Physics, Beijing 100084, People's Republic of China
Shree Narayanan - Department of Electrical and Computer Engineering , Virginia Tech, Blacksburg, VA 24061, USA
Masoud Agah - Department of Electrical and Computer Engineering , Virginia Tech, Blacksburg, VA 24061, USA
Eric A Hoffman - University of Iowa Department of Radiology, Iowa City, IA 52242, USA
Hengyong Yu - Wake Forest University Health Sciences Biomedical Imaging Division, VT-WFU School of Biomedical Eng. and Sciences, Winston-Salem, NC 27157, USA
Ge Wang - Rensselaer Polytechnic Institute Biomedical Imaging Center, Troy, NY 12180, USA
Resource Type: Journal article
Publication Details: Physics in medicine & biology, Vol.58(12), pp.4297-4314
DOI: 10.1088/0031-9155/58/12/4297
PMID: 23732478
PMCID: PMC3732817
NLM abbreviation: Phys Med Biol
ISSN: 0031-9155
eISSN: 1361-6560
Publisher: IOP Publishing
Language: English
Date published: 06/21/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051890302771

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