Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection

Subrata Sarkar; Seetha Shankaran; Abbot R Laptook; Beena G Sood; Barbara Do; Barbara J Stoll; Krisa P Van Meurs; Edward F Bell; Abhik Das; John Barks; Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1055/s-0035-1545666

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Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection

Journal article

Peer reviewed

Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection

Subrata Sarkar, Seetha Shankaran, Abbot R Laptook, Beena G Sood, Barbara Do, Barbara J Stoll, Krisa P Van Meurs, Edward F Bell, Abhik Das, John Barks, …

American journal of perinatology, Vol.32(10), pp.973-979

08/2015

DOI: 10.1055/s-0035-1545666

PMCID: PMC4697863

PMID: 25730135

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Abstract

The aim of this study is to determine whether the cystic periventricular leukomalacia (cPVL) detection rate differs between imaging studies performed at different time points. We retrospectively reviewed the prospectively collected data of 31,708 infants from the NICHD Neonatal Research Network. Inclusion criteria were infants < 1,000 g birth weight or < 29 weeks' gestational age who had cranial imaging performed using both early criterion (cranial ultrasound [CUS] < 28 days chronological age) and late criterion (CUS, magnetic resonance imaging, or computed tomography closest to 36 weeks postmenstrual age [PMA]). We compared the frequency of cPVL diagnosed by early and late criteria. About 664 (5.2%) of the 12,739 infants who met inclusion criteria had cPVL using either early or late criteria; 569 using the late criterion, 250 using the early criterion, and 155 patients at both times. About 95 (14.3%) of 664 cPVL cases seen on early imaging were no longer visible on repeat screening closest to 36 weeks PMA. Such disappearance of cPVL was more common in infants < 26 weeks' gestation versus infants of 26 to 28 weeks' gestation (18.5 vs. 11.5%; p = 0.013). Cranial imaging at both < 28 days chronological age and closest to 36 weeks PMA improves cPVL detection, especially for more premature infants.

Magnetic Resonance Imaging

Infant, Extremely Low Birth Weight

Brain - diagnostic imaging

Humans

Tomography, X-Ray Computed

Neonatal Screening

Echoencephalography

Time Factors

Infant, Premature

Brain - pathology

Infant, Extremely Premature

Retrospective Studies

Leukomalacia, Periventricular - diagnosis

Infant, Newborn

Details

Title: Subtitle: Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection
Creators: Subrata Sarkar - Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
Seetha Shankaran - Department of Pediatrics, Wayne State University, Detroit, Michigan
Abbot R Laptook - Department of Pediatrics, Women and Infants' Hospital, Brown University, Providence, Rhode Island
Beena G Sood - Department of Pediatrics, Wayne State University, Detroit, Michigan
Barbara Do - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina
Barbara J Stoll - Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia
Krisa P Van Meurs - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California
Edward F Bell - Department of Pediatrics, University of Iowa, Iowa City, Iowa
Abhik Das - Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland
John Barks - Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Resource Type: Journal article
Publication Details: American journal of perinatology, Vol.32(10), pp.973-979
DOI: 10.1055/s-0035-1545666
PMID: 25730135
PMCID: PMC4697863
NLM abbreviation: Am J Perinatol
ISSN: 0735-1631
eISSN: 1098-8785
Grant note: UG1 HD021385 / NICHD NIH HHS UG1 HD053109 / NICHD NIH HHS U10 HD036790 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS Z99 HD999999 / Intramural NIH HHS UG1 HD027880 / NICHD NIH HHS
Language: English
Date published: 08/2015
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984093331602771

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