Journal article
Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement
JAMA : the journal of the American Medical Association, Vol.320(9), pp.911-917
09/04/2018
DOI: 10.1001/jama.2018.11785
PMID: 30193283
Abstract
Untreated syphilis infection in pregnant women can be transmitted to the fetus (congenital syphilis) at any time during pregnancy or at birth. Congenital syphilis is associated with stillbirth, neonatal death, and significant morbidity in infants (eg, bone deformities and neurologic impairment). After a steady decline from 2008 to 2012, cases of congenital syphilis markedly increased from 2012 to 2106, from 8.4 to 15.7 cases per 100 000 live births (an increase of 87%). At the same time, national rates of syphilis increased among women of reproductive age.
To update the US Preventive Services Task Force (USPSTF) 2009 recommendation on screening for syphilis infection in pregnant women.
The USPSTF commissioned a reaffirmation evidence update to identify new and substantial evidence sufficient enough to change its prior recommendation. Given the established benefits and practice of screening for syphilis in pregnant women, the USPSTF targeted its evidence review on the direct benefits of screening on the prevention of congenital syphilis morbidity and mortality and the harms of screening for and treatment of syphilis infection in pregnant women.
Using a reaffirmation process, the USPSTF found that accurate screening algorithms are available to identify syphilis infection. Effective treatment with antibiotics can prevent congenital syphilis and significantly decrease adverse pregnancy outcomes, with small associated harms, providing an overall substantial health benefit. Therefore, the USPSTF reaffirms its previous conclusion that there is convincing evidence that screening for syphilis infection in pregnant women provides substantial benefit.
The USPSTF recommends early screening for syphilis infection in all pregnant women. (A recommendation).
Details
- Title: Subtitle
- Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement
- Creators
- Susan J Curry - University of IowaAlex H Krist - Virginia Commonwealth UniversityDouglas K Owens - Stanford UniversityMichael J Barry - Harvard UniversityAaron B Caughey - Oregon Health & Science UniversityKarina W Davidson - Columbia UniversityChyke A Doubeni - University of PennsylvaniaJohn W Epling Jr - Virginia TechAlex R Kemper - Nationwide Children's HospitalMartha Kubik - Temple UniversityAnn E Kurth - Yale UniversityC Seth Landefeld - University of Alabama at BirminghamCarol M Mangione - University of California, Los AngelesMaureen G Phipps - Brown UniversityMichael Silverstein - Boston UniversityMelissa A Simon - Northwestern UniversityChien-Wen Tseng - Honolulu UniversityJohn B Wong - Tufts UniversityUS Preventive Services Task Force
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.320(9), pp.911-917
- DOI
- 10.1001/jama.2018.11785
- PMID
- 30193283
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Grant note
- UL1 TR002649 / NCATS NIH HHS
- Language
- English
- Date published
- 09/04/2018
- Academic Unit
- Health Management and Policy; Community and Behavioral Health
- Record Identifier
- 9984366281902771
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