Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Robert D Brown; John Huston III; Richard Hornung; Tatiana Foroud; David F Kallmes; Dawn Kleindorfer; Irene Meissner; Daniel Woo; Laura Sauerbeck; Joseph Broderick; Familial Intracranial Aneurysm (FIA) Investigators

doi:10.3171/JNS/2008/108/6/1132

Back

Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Journal article

Peer reviewed

Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Robert D Brown, John Huston III, Richard Hornung, Tatiana Foroud, David F Kallmes, Dawn Kleindorfer, Irene Meissner, Daniel Woo, Laura Sauerbeck, Joseph Broderick, …

Journal of neurosurgery, Vol.108(6), pp.1132-1138

06/2008

DOI: 10.3171/JNS/2008/108/6/1132

PMCID: PMC4190025

PMID: 18518716

Files and links (1)

url

http://doi.org/10.3171/JNS/2008/108/6/1132View

Open Access

Abstract

Object Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.

Details

Title: Subtitle: Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection
Creators: Robert D Brown - 1Departments of Neurology and
John Huston III - 2Neuroradiology, Mayo Clinic, Rochester, Minnesota
Richard Hornung
Tatiana Foroud - 5Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana
David F Kallmes - 2Neuroradiology, Mayo Clinic, Rochester, Minnesota
Dawn Kleindorfer - 3Departments of Neurology
Irene Meissner - 1Departments of Neurology and
Daniel Woo - 3Departments of Neurology
Laura Sauerbeck - 3Departments of Neurology
Joseph Broderick - 3Departments of Neurology
Familial Intracranial Aneurysm (FIA) Investigators
Contributors: Colin P Derdeyn (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Journal of neurosurgery, Vol.108(6), pp.1132-1138
DOI: 10.3171/JNS/2008/108/6/1132
PMID: 18518716
PMCID: PMC4190025
NLM abbreviation: J Neurosurg
ISSN: 0022-3085
eISSN: 1933-0693
Language: English
Date published: 06/2008
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020605602771

Metrics

25 Record Views

78 Times Cited - Web of Science