Journal article
Screening for carcinoid heart disease: Trends and future Perspectives
International journal of cardiology. Cardiovascular risk and prevention, Vol.22, 200293
09/2024
DOI: 10.1016/j.ijcrp.2024.200293
PMCID: PMC11190706
PMID: 38911359
Abstract
Screening for carcinoid heart disease (CHD), has historically lacked consensus expert guidelines. In 2017, the North American Neuroendocrine Tumor Society (NANETS) released expert recommendations for CHD screening among NET patients to improve CHD detection. The objective of this study is to evaluate CHD screening trends and utility of screening guidelines over more than two decades at a single tertiary care center.
Patients with NETs referred for abdominal surgical evaluation at a single tertiary care center were included, 300 patients from 1999 to 2018 and 34 patients from 2021 to 2022. Lab values for the following NANETS-proposed criteria at any point during their treatments were recorded: NETs with liver metastasis, blood serotonin >5 times upper limit of normal (>1000 ng/mL), NT-ProBNP >260 pg/mL and clinical features suggestive of CHD.
85 % (285/334) of patients included in this study met one or more expert-recommended CHD screening criteria. However, 40 % (132/285) of patients meeting one or more criteria received CHD screening via echocardiogram at some point following NET diagnosis. While rates of screening for patients increased from the first decade to the second decade (32 % vs 40.6 %), the rates were much higher after guideline publication (70 %, 24/34). Furthermore, patients meeting multiple screening criteria were more likely to have evidence of structural valve disease.
Results of this study suggest that utilization of these four expert-recommended screening criteria have greatly increased rates of CHD screening via echocardiogram and could assist in improving early CHD detection, especially for patients meeting multiple criteria.
Details
- Title: Subtitle
- Screening for carcinoid heart disease: Trends and future Perspectives
- Creators
- Bryan Mouser - University of IowaJames R. Howe - University of IowaOlivia Atari - University of IowaJoseph S. Dillon - University of IowaChandrikha Chandrasekharan - University of IowaKalpaj R. Parekh - University of IowaMohammad A. Bashir - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology. Cardiovascular risk and prevention, Vol.22, 200293
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijcrp.2024.200293
- PMID
- 38911359
- PMCID
- PMC11190706
- ISSN
- 2772-4875
- eISSN
- 2772-4875
- Grant note
- Iowa SPORE for Neuroendocrine Tumors: P50 CA174521
These authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.** JRH, JSD, CC were supported by the Iowa SPORE for Neuroendocrine Tumors (P50 CA174521) . JSD, CC, KRP, MAB are members of the University of Iowa ENETS Center of Excellence for neuroendocrine tumors.
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Anatomy and Cell Biology; Hematology, Oncology, and Blood & Marrow Transplantation; Surgery; Fraternal Order of Eagles Diabetes Research Center; Cardiothoracic Surgery; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984642760102771
Metrics
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