Journal article
Screening technologies for unusual and challenging targets
The FASEB journal, Vol.25, pp.314.1-314.1
04/2011
DOI: 10.1096/fasebj.25.1_supplement.314.1
Abstract
The Small Molecule Discovery Center (SMDC) at UCSF offers researchers access to drug‐discovery technologies, including HTS, fragment‐based ligand discovery, and medicinal chemistry. This talk will summarize recent projects in neglected tropical diseases done in collaboration with the Sandler Center for Drug Discovery and SF State University and will touch on the expanding roles of academic centers in driving innovation in drug discovery.
With tropical diseases, academics have an important opportunity to develop technologies and evaluate new therapeutic targets. Schistosomiasis is an example of a parasitic disease that infects hundreds of millions of people, yet is widely neglected by the drug‐discovery world. We have taken a high‐content imaging approach to screen for compounds that kill the causative agent of Schistosomiasis. In developing this imaging technology, we have solved problems with automating sample preparation and data collection, and we are developing a suite of image analysis tools that define helminth phenotypes based on shape and motion descriptors. These tools have allowed us to increase our throughput for drug screening and to deepen our understanding of the mechanism of action of anti‐helminth compounds. This project is supported by NIH (R01AI089896‐01) and the Sandler Center.
Details
- Title: Subtitle
- Screening technologies for unusual and challenging targets
- Creators
- Michelle R. Arkin - University of California, San FranciscoSteven Chen - University of California, San FranciscoBrian Suzuki - University of California, San FranciscoVlad Popescu - San Francisco State UniversityAdam Renslo - University of California, San FranciscoJim A Wells - University of California, San FranciscoRahul Singh - San Francisco State UniversityConor R. Caffrey - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.25, pp.314.1-314.1
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.314.1
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (R01AI089896‐01) Sandler Center
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Computer Science
- Record Identifier
- 9984455938202771
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