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Scrotal Cancer Incidence Rates and Trends—United States, 1999-2020
Journal article   Peer reviewed

Scrotal Cancer Incidence Rates and Trends—United States, 1999-2020

Jacqueline M. Mix, Sameer V. Gopalani, Maureen Miller, Mona Saraiya, Teresa M. Darragh, Charles F. Lynch, Trevor D. Thompson, Virginia Senkomago, April Greek, Thomas C. Tucker, …
Urology (Ridgewood, N.J.), Vol.192, pp.69-73
10/2024
DOI: 10.1016/j.urology.2024.06.048
PMCID: PMC11439577
PMID: 38936628

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Abstract

To examine population-level scrotal cancer incidence rates and trends among adult men in the United States. Data from the United States Cancer Statistics, covering approximately 96% of the United States population, were analyzed to calculate age-standardized incidence rates of scrotal cancer among men aged 18 years and older from 1999 to 2020. Trends in incidence rates were evaluated by age, race and ethnicity, Census region, and histology using joinpoint regression. Overall, 4,669 men were diagnosed with scrotal cancer (0.20 per 100,000). Incidence rates were highest among men aged 70 years and older (0.82 per 100,000). Rates were higher among non-Hispanic Asian or Pacific Islander men (0.31 per 100,000) compared to other race and ethnicity groups. The most common histologic subtypes were squamous cell carcinoma (35.9%), extramammary Paget disease (20.8%), and sarcoma (20.5%). Incidence rates decreased by 2.9% per year from 1999 to 2019 for non-Hispanic Asian or Pacific Islander men, decreased by 8.1% per year from 1999 to 2006 for basal cell carcinomas, and increased by 1.8% per year from 1999 to 2019 for extramammary Paget disease; otherwise, rates remained stable for all other variables examined. While scrotal cancer incidence rates were higher than previously reported, rates were still low and stable over time.

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