Journal article
Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries
Journal of neurovirology, Vol.19(2), pp.181-185
04/01/2013
DOI: 10.1007/s13365-013-0155-0
PMCID: PMC3644002
PMID: 23456953
Abstract
Virological confirmation of varicella zoster virus (VZV) vasculopathy is provided by presence of virus in the cerebral arteries, frequently associated with inflammation. Yet, cerebral arteries from normal subjects have never been studied for VZV DNA or antigen. We analyzed 63 human cerebral arteries from 45 subjects for VZV DNA and antigen, control herpes simplex virus (HSV)-1 DNA and antigen, and leukocyte-specific CD45 antigen. No cerebral arteries contained VZV or HSV-1 DNA or antigen; eight arteries from seven subjects contained leukocytes expressing CD45. Thus, the presence of VZV antigen in cerebral arteries of patients with stroke is likely to be clinically significant.
Details
- Title: Subtitle
- Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries
- Creators
- Maria A. Nagel - University of Colorado DenverAlexander Choe - University of Colorado DenverNelly Khmeleva - University of Colorado DenverLindsey Overton - University of Colorado DenverApril Rempel - University of Colorado DenverAnn Wyborny - University of Colorado DenverIgor Traktinskiy - University of Colorado DenverDon Gilden - University of Colorado Denver
- Resource Type
- Journal article
- Publication Details
- Journal of neurovirology, Vol.19(2), pp.181-185
- DOI
- 10.1007/s13365-013-0155-0
- PMID
- 23456953
- PMCID
- PMC3644002
- NLM abbreviation
- J Neurovirol
- ISSN
- 1355-0284
- eISSN
- 1538-2443
- Publisher
- Springer Nature
- Number of pages
- 5
- Grant note
- P01AG032958 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG032958 / Public Health Service from the National Institutes of Health K08NS067070 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 04/01/2013
- Academic Unit
- Neurology
- Record Identifier
- 9984827337602771
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