Journal article
Searching for molecular hypoxia sensors among oxygen-dependent enzymes
eLife, Vol.12, 87705
07/26/2023
DOI: 10.7554/eLife.87705
PMCID: PMC10371230
PMID: 37494095
Abstract
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes exist among aerobic organisms, raising the possibility that additional sensors remain to be discovered. This review summarizes known and potential hypoxia sensors among human O-2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
Details
- Title: Subtitle
- Searching for molecular hypoxia sensors among oxygen-dependent enzymes
- Creators
- Li Li - University of California, San FranciscoSusan Shen - University of California, San FranciscoPhilip Bickler - University of California, San FranciscoMatthew P. Jacobson - University of California, San FranciscoLani F. Wu - University of California, San FranciscoSteven J. Altschuler - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.12, 87705
- Publisher
- eLIFE SCIENCES PUBL LTD
- DOI
- 10.7554/eLife.87705
- PMID
- 37494095
- PMCID
- PMC10371230
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Number of pages
- 35
- Grant note
- R38AG070171; R25MH0602 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA LT000908/2020-C / Human Frontier Science Program HR0011-19-2-0018 / Defense Advanced Research Projects Agency; United States Department of Defense; Defense Advanced Research Projects Agency (DARPA)
- Language
- English
- Date published
- 07/26/2023
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984618510802771
Metrics
2 Record Views