Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization

C Clayton Hazelett; Charles Yeaman

doi:10.1371/journal.pone.0039602

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Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization

Journal article

Open access

Peer reviewed

Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization

C Clayton Hazelett and Charles Yeaman

PloS one, Vol.7(6), pp.e39602-e39602

2012

DOI: 10.1371/journal.pone.0039602

PMCID: PMC3382198

PMID: 22761837

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Abstract

Metastasis is a complex process during which several gross cellular changes occur. Cells must dissociate from the tumor mass and gain the ability to degrade extracellular matrix and migrate in order to ultimately attach and form a satellite tumor. Regulation of the actin cytoskeleton is an indispensible aspect of cell migration, and many different factors have been implicated in this process. We identified interactions between RalA and its effectors in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. Blocking RalA-Exocyst binding caused significant morphological changes and defects in single and coordinated cell migration.

Vesicular Transport Proteins - metabolism

Humans

Vesicular Transport Proteins - genetics

Actins - metabolism

Cytoskeleton - genetics

Cell Movement - physiology

Neoplasm Metastasis - genetics

ral GTP-Binding Proteins - metabolism

Cell Line, Tumor

Cytoskeleton - metabolism

Cell Polarity - physiology

ral GTP-Binding Proteins - genetics

Cell Shape - physiology

Details

Title: Subtitle: Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization
Creators: C Clayton Hazelett - Department of Anatomy and Cell Biology Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
Charles Yeaman
Resource Type: Journal article
Publication Details: PloS one, Vol.7(6), pp.e39602-e39602
DOI: 10.1371/journal.pone.0039602
PMID: 22761837
PMCID: PMC3382198
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: 11PRE5670009 / PHS HHS R01 GM067002 / NIGMS NIH HHS GM067002 / NIGMS NIH HHS
Language: English
Date published: 2012
Academic Unit: Anatomy and Cell Biology; Internal Medicine
Record Identifier: 9984025368502771

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