Second Primary Lung Cancer After Head and Neck Cancer: Implications for Screening Computed Tomography

Nitin A Pagedar; Asitha Jayawardena; Mary E Charlton; Henry T Hoffman

doi:10.1177/0003489415582259

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Second Primary Lung Cancer After Head and Neck Cancer: Implications for Screening Computed Tomography

Journal article

Open access

Peer reviewed

Second Primary Lung Cancer After Head and Neck Cancer: Implications for Screening Computed Tomography

Nitin A Pagedar, Asitha Jayawardena, Mary E Charlton and Henry T Hoffman

Annals of otology, rhinology & laryngology, Vol.124(10), pp.765-769

10/2015

DOI: 10.1177/0003489415582259

PMCID: PMC5296183

PMID: 25881583

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Abstract

Recent guidelines recommend chest computed tomography (CT) for smokers based on studies of individuals aged 55 to 74 years with 30-pack year smoking to detect lung cancers. Some have postulated that a prior diagnosis of head and neck cancer (HNC) should also warrant lung cancer screening with CT, but no studies have demonstrated benefit in this population. Our goal was to compare survival of HNC patients with second primary lung cancers (SPLCs) with survival of lung cancer-only patients to determine if detecting early stage lung cancer in those with prior HNC could lead to similar survival benefits. Survival estimates for patients with early stage SPLC diagnosed between ages 55 and 74 at least 1 year after HNC diagnosis were compared with patients with early stage lung cancer and no other cancers. Median survival of patients with lung cancer only was 38 months. Median survival after SPLC was 22 months. History of head and neck cancer predicted poorer survival after lung cancer diagnosis, P<.0001. Survival outcomes after early lung cancer are worse after HNC. This finding diminishes the effectiveness of chest CT as a screening modality for HNC survivors, and further study should be undertaken prior to its routine use.

United States - epidemiology

Early Detection of Cancer - methods

Outcome Assessment (Health Care)

Lung Neoplasms - mortality

Humans

Middle Aged

Risk Factors

Tomography, X-Ray Computed - methods

Lung Neoplasms - pathology

Male

Neoplasms, Second Primary - mortality

Mass Screening - methods

Head and Neck Neoplasms - pathology

Neoplasms, Second Primary - etiology

Lung Neoplasms - etiology

Smoking - epidemiology

Head and Neck Neoplasms - epidemiology

Survival Analysis

Female

Aged

Neoplasms, Second Primary - pathology

Early Detection of Cancer - statistics & numerical data

Details

Title: Subtitle: Second Primary Lung Cancer After Head and Neck Cancer: Implications for Screening Computed Tomography
Creators: Nitin A Pagedar - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA nitin-pagedar@uiowa.edu
Asitha Jayawardena - Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee, USA
Mary E Charlton - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA
Henry T Hoffman - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.124(10), pp.765-769
DOI: 10.1177/0003489415582259
PMID: 25881583
PMCID: PMC5296183
NLM abbreviation: Ann Otol Rhinol Laryngol
ISSN: 0003-4894
eISSN: 1943-572X
Publisher: United States
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 10/2015
Academic Unit: Health Management and Policy; Epidemiology; Radiation Oncology; Otolaryngology
Record Identifier: 9983995044402771

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