Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder

Mark J Niciu; Dawn F Ionescu; Daniel C Mathews; Erica M Richards; Carlos A Zarate

doi:10.1017/S1092852913000138

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Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder

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Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder

Mark J Niciu, Dawn F Ionescu, Daniel C Mathews, Erica M Richards and Carlos A Zarate

CNS spectrums, Vol.18(5), pp.242-251

10/2013

DOI: 10.1017/S1092852913000138

PMCID: PMC3936782

PMID: 23472710

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https://www.ncbi.nlm.nih.gov/pmc/articles/3936782View

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Abstract

In this second of two articles on second messenger/signal transduction cascades in major mood disorders, we will review the evidence in support of intracellular dysfunction and its rectification in the etiopathogenesis and treatment of bipolar disorder (BD). The importance of these cascades is highlighted by lithium's (the gold standard in BD psychopharmacology) ability to inhibit multiple critical loci in second messenger/signal transduction cascades including protein kinase C (involved in the IP3/PIP2 pathway) and GSK-3β (canonically identified in the Wnt/Fz/Dvl/GSK-3β cascade). As a result, and like major depressive disorder (MDD), more recent pathophysiological studies and rational therapeutic targets have been directed at these and other intracellular mediators. Even in the past decade, intracellular dysfunction in numerous neuroprotective/apoptotic cascades appears important in the pathophysiology and may be a future target for pharmacological interventions of BD.

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Title: Subtitle: Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder
Creators: Mark J Niciu - 1National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, Bethesda, Maryland, USA
Dawn F Ionescu - 1National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, Bethesda, Maryland, USA
Daniel C Mathews - 1National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, Bethesda, Maryland, USA
Erica M Richards - 1National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, Bethesda, Maryland, USA
Carlos A Zarate - 1National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, Bethesda, Maryland, USA
Resource Type: Journal article
Publication Details: CNS spectrums, Vol.18(5), pp.242-251
DOI: 10.1017/S1092852913000138
PMID: 23472710
PMCID: PMC3936782
NLM abbreviation: CNS Spectr
ISSN: 1092-8529
eISSN: 2165-6509
Publisher: Cambridge University Press; New York, USA
Number of pages: 10
Alternative title: Second messenger/signal transduction pathways, part II; M. J. Niciu etal.
Language: English
Date published: 10/2013
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003989802771

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