Second primary cancer after treatment for cervical cancer. An international cancer registries study

R A Kleinerman; J D   Boice Jr; H H Storm; P Sparen; A Andersen; E Pukkala; C F Lynch; B F Hankey; J T Flannery

doi:10.1002/1097-0142(19950801)76:3<442::AID-CNCR2820760315>3.0.CO;2-L

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Second primary cancer after treatment for cervical cancer. An international cancer registries study

Journal article

Open access

Peer reviewed

Second primary cancer after treatment for cervical cancer. An international cancer registries study

R A Kleinerman, J D Boice Jr, H H Storm, P Sparen, A Andersen, E Pukkala, C F Lynch, B F Hankey and J T Flannery

Cancer, Vol.76(3), pp.442-452

08/01/1995

DOI: 10.1002/1097-0142(19950801)76:3<442::AID-CNCR2820760315>3.0.CO;2-L

PMID: 8625126

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https://doi.org/10.1002/1097-0142(19950801)76:33.0.CO;2-LView

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Abstract

The pattern of second cancers after treatment for cervical cancer provides important information on the risk of radiation-induced malignancies. Large numbers of women survive many years and can be studied for late effects. Incident second cancers in 86,193 patients with cervical cancer reported to 13 population-based cancer registries in 5 countries were evaluated to estimate the risk of second cancer among very long term survivors. Overall, 7543 second cancers were observed versus 6015 cancers expected based on population rates (observed/expected = 1.2). Lung cancer accounted for nearly half of the excess cancers. Among the 49,828 women treated with radiation, 3750 survived 30 or more years and a two-fold risk of cancers of heavily irradiated organs was seen. Most of the excess cancers were of the rectum, vagina, vulva, ovary, and bladder. Patterns of risk over time since treatment were consistent with a radiation etiology. Significant increases of nonchronic lymphocytic leukemia and cancers of the bone and kidney were also linked to radiotherapy. Women treated surgically were also at significant risk of second cancers, in all likelihood related to cigarette smoking and risk factors similar to those of cervical cancer. Curative therapy for cervical cancer results in large numbers of long term survivors who develop second cancers very late in life. Radiation is an important cause of this increase and there is no evidence that risk returns to normal levels.

Radiotherapy Dosage

United States - epidemiology

SEER Program

Uterine Cervical Neoplasms - radiotherapy

Humans

Neoplasms, Radiation-Induced - etiology

Risk Factors

Europe - epidemiology

Female

Radiotherapy - adverse effects

Neoplasms, Radiation-Induced - epidemiology

Details

Title: Subtitle: Second primary cancer after treatment for cervical cancer. An international cancer registries study
Creators: R A Kleinerman - Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-7362, USA
J D Boice Jr
H H Storm
P Sparen
A Andersen
E Pukkala
C F Lynch
B F Hankey
J T Flannery
Resource Type: Journal article
Publication Details: Cancer, Vol.76(3), pp.442-452
Publisher: United States
DOI: 10.1002/1097-0142(19950801)76:3<442::AID-CNCR2820760315>3.0.CO;2-L
PMID: 8625126
ISSN: 0008-543X
eISSN: 1097-0142
Grant note: N01-CP-85626-01 / NCI NIH HHS N01-CP-85638-02 / NCI NIH HHS N01-CP-85639-03 / NCI NIH HHS
Language: English
Date published: 08/01/1995
Academic Unit: Epidemiology
Record Identifier: 9983995156202771

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