Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia

Kharah M Ross; Rebecca J Baer; Kelli Ryckman; Sky K Feuer; Gretchen Bandoli; Christina Chambers; Elena Flowers; Liang Liang; Scott Oltman; Christine Dunkel Schetter; Laura Jelliffe-Pawlowski

doi:10.1038/s41372-018-0275-8

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Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia

Journal article

Open access

Peer reviewed

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia

Kharah M Ross, Rebecca J Baer, Kelli Ryckman, Sky K Feuer, Gretchen Bandoli, Christina Chambers, Elena Flowers, Liang Liang, Scott Oltman, Christine Dunkel Schetter, …

Journal of perinatology, Vol.39(2), pp.314-320

02/2019

DOI: 10.1038/s41372-018-0275-8

PMCID: PMC6760589

PMID: 30518800

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Abstract

Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia. A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios. Higher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia. Among women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.

Multivariate Analysis

Pregnancy Complications - blood

Humans

Risk Factors

Logistic Models

Biomarkers - blood

Pregnancy Complications - diagnosis

Premature Birth - blood

Premature Birth - diagnosis

Gestational Age

Case-Control Studies

Pregnancy

Young Adult

Pre-Eclampsia - blood

Adult

Female

Pregnancy Trimester, Second - blood

Infant, Newborn

Pre-Eclampsia - diagnosis

Details

Title: Subtitle: Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia
Creators: Kharah M Ross - Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA. kross@psych.ucla.edu
Rebecca J Baer - Department of Pediatrics, University of California San Diego, San Diego, CA, USA
Kelli Ryckman - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Sky K Feuer - California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA
Gretchen Bandoli - California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA
Christina Chambers - California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA
Elena Flowers - Department of Physiological Nursing, University of California School of Nursing, San Francisco, CA, USA
Liang Liang - Department of Genetics, Stanford University School of Medicine, Palo Alto, CA, USA
Scott Oltman - Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, USA
Christine Dunkel Schetter - Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
Laura Jelliffe-Pawlowski - Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, USA
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.39(2), pp.314-320
DOI: 10.1038/s41372-018-0275-8
PMID: 30518800
PMCID: PMC6760589
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: United States
Grant note: RC2 HL101748 / NHLBI NIH HHS R01 HD052953 / NICHD NIH HHS R01 HD073491 / NICHD NIH HHS UL1 TR001085 / NCATS NIH HHS K12 HD000849 / NICHD NIH HHS R01 HD072021 / NICHD NIH HHS R01 HD057192 / NICHD NIH HHS SDR 10-180 / HSRD VA
Language: English
Date published: 02/2019
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983995053502771

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