Secondary CD8+ T-cell responses are controlled by systemic inflammation

Thomas C Wirth; Matthew D Martin; Gabriel Starbeck-Miller; John T Harty; Vladimir P Badovinac

doi:10.1002/eji.201040730

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Secondary CD8+ T-cell responses are controlled by systemic inflammation

Journal article

Open access

Peer reviewed

Secondary CD8+ T-cell responses are controlled by systemic inflammation

Thomas C Wirth, Matthew D Martin, Gabriel Starbeck-Miller, John T Harty and Vladimir P Badovinac

European journal of immunology, Vol.41(5), pp.1321-1333

05/2011

DOI: 10.1002/eji.201040730

PMCID: PMC3083480

PMID: 21425157

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Abstract

Repeated infections and experimental prime-boost regimens frequently result in the generation of secondary (2°) CD8 + T-cell responses. In contrast to primary (1°) CD8 + T cells, the parameters that influence the abundance and phenotype of 2° effector and memory CD8 + T-cell populations are largely unknown. Here, we analyze the impact of different booster infections, Ag curtailment, and systemic inflammation on the quality and quantity of secondary CD8 + T-cell responses. We show that similar to 1° CD8 + T-cell responses, the phenotype of 2° effector and memory CD8 + T-cell populations is critically dependent on the nature of the infectious pathogen and the inflammatory milieu early after infection. In addition, systemic inflammation increases the number of 2° effector and memory CD8 + T cells after booster infections and immunizations. Therefore, our data reveal new means to boost the number of 2° effector and memory CD8 + T cells in prime-boost regimens and show a surprisingly high degree of plasticity in 2° memory CD8 + T-cell phenotype that is controlled by systemic inflammation.

Memory

Inflammation

Secondary responses

Details

Title: Subtitle: Secondary CD8+ T-cell responses are controlled by systemic inflammation
Creators: Thomas C Wirth - Department of Microbiology, University of Iowa, Iowa City, IA, USA
Matthew D Martin - Department of Pathology, University of Iowa, Iowa City, IA, USA
Gabriel Starbeck-Miller - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA
John T Harty - Department of Microbiology, University of Iowa, Iowa City, IA, USA
Vladimir P Badovinac - Department of Pathology, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: European journal of immunology, Vol.41(5), pp.1321-1333
DOI: 10.1002/eji.201040730
PMID: 21425157
PMCID: PMC3083480
NLM abbreviation: Eur J Immunol
ISSN: 0014-2980
eISSN: 1521-4141
Grant note: R01 AI083286-01 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
Language: English
Date published: 05/2011
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984046909002771

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