Journal article
Secondary Conditions Among Males With Duchenne or Becker Muscular Dystrophy
Journal of child neurology, Vol.32(7), pp.663-670
06/2017
DOI: 10.1177/0883073817701368
PMCID: PMC5502756
PMID: 28393671
Abstract
Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively described. Two hundred nine caregivers of affected males (aged 3-31 years) identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network completed a mailed survey that included questions about secondary conditions impacting multiple body functions. The 5 most commonly reported conditions in males with Duchenne were cognitive deficits (38.4%), constipation (31.7%), anxiety (29.3%), depression (27.4%), and obesity (19.5%). Higher frequencies of anxiety, depression, and kidney stones were found among nonambulatory males compared to ambulatory males. Attention-deficit hyperactivity disorder (ADHD) was more common in ambulatory than nonambulatory males. These data support clinical care recommendations for monitoring of patients with Duchenne or Becker muscular dystrophy by a multidisciplinary team to prevent and treat conditions that may be secondary to the diagnosis.
Details
- Title: Subtitle
- Secondary Conditions Among Males With Duchenne or Becker Muscular Dystrophy
- Creators
- Rebecca Latimer - 1 Cardiogenetic Testing Services, GeneDx, Gaithersburg, MD, USANatalie Street - 2 Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USAKristin Caspers Conway - 3 Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USAKathy James - 4 University of Colorado, Denver, Aurora, CO, USAChristopher Cunniff - 5 Department of Pediatrics, Weill Cornell Medical College, New York, NY, USAJoyce Oleszek - 6 Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO, USADeborah Fox - 7 New York State Department of Health, Albany, NY, USAEmma Ciafaloni - 8 University of Rochester Medical Center, Rochester, NY, USAChristina Westfield - 7 New York State Department of Health, Albany, NY, USAPangaja Paramsothy - 2 Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USAMuscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR net)
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Journal of child neurology, Vol.32(7), pp.663-670
- DOI
- 10.1177/0883073817701368
- PMID
- 28393671
- PMCID
- PMC5502756
- NLM abbreviation
- J Child Neurol
- ISSN
- 0883-0738
- eISSN
- 1708-8283
- Grant note
- U01 DD000189 / NCBDD CDC HHS U01 DD000187 / NCBDD CDC HHS U01 DD001126 / NCBDD CDC HHS U01 DD001123 / NCBDD CDC HHS CC999999 / Intramural CDC HHS U01 DD000190 / NCBDD CDC HHS U01 DD001119 / NCBDD CDC HHS U01 DD000191 / NCBDD CDC HHS
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214785102771
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