Journal article
Secondary Neurodegeneration: A General Approach to Axonal and Transaxonal Degeneration
Neurographics (Oak Brook, Ill. 2011), Vol.11(2), pp.111-126
03/01/2021
DOI: 10.3174/ng.2000050
Abstract
CNS WM tracts are mainly composed of axons, and when these structures undergo apoptosis or lose their integrity, neurodegeneration may occur. Secondary neuronal degeneration can be classified as axonal degeneration and involves only the first neuron in a pathway (Wallerian degeneration
of the corticospinal tract being its prototype) or be classified as transaxonal degeneration and involve more than a single neuron in a common pathway, usually a closed neuronal circuit, in specific tracts, such as the dentate-rubro-olivary tract, tracts of the limbic system, corticopontocerebellar
tract, cranial nerve tracts, and nigrostriatal pathway. This study aimed to review the anatomy of the main CNS tracts susceptible to secondary neuronal degeneration and to illustrate, through different imaging modalities, the findings associated with this poorly explored and understood process
involved in the pathophysiologic substrate of numerous neurologic diseases.Learning Objective: Recognize the anatomy of the main CNS tracts susceptible to secondary neuronal degeneration and identify its main imaging findings in different imaging modalities.
Details
- Title: Subtitle
- Secondary Neurodegeneration: A General Approach to Axonal and Transaxonal Degeneration
- Creators
- F.B. AssunçãoT.L.P.D. ScoppettaB S Yonekura InadaL.D.A. MartinsE.O NarvaezM.D SoldatelliL.F. FreitasV.H.R MarussiC.M.S CamposL.L.F.D. Amaral
- Resource Type
- Journal article
- Publication Details
- Neurographics (Oak Brook, Ill. 2011), Vol.11(2), pp.111-126
- Publisher
- American Society of Neuroradiology and the NER Foundation
- DOI
- 10.3174/ng.2000050
- ISSN
- 2637-8329
- eISSN
- 2637-8329
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984697637902771
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