Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype

Ali Jabbari; John T Harty

doi:10.1084/jem.20052237

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Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype

Journal article

Open access

Peer reviewed

Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype

Ali Jabbari and John T Harty

The Journal of experimental medicine, Vol.203(4), pp.919-932

04/17/2006

DOI: 10.1084/jem.20052237

PMCID: PMC2118270

PMID: 16567385

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Abstract

The formation of memory CD8 T cells is an important goal of vaccination. However, although widespread use of booster immunizations in humans generates secondary and tertiary CD8 T cell memory, experimental data are limited to primary CD8 T cell memory. Here, we show that, compared with primary memory CD8 T cells, secondary memory CD8 T cells exhibit substantially delayed conversion to a central-memory phenotype, as determined by CD62L expression and interleukin (IL)-2 production. This delayed conversion to a central-memory phenotype correlates with reduced basal proliferation and responsiveness to IL-15, although in vitro coculture with a high concentration of IL-15 is capable of inducing proliferation and CD62L upregulation. Functionally, secondary memory CD8 T cells are more protective in vivo on a per cell basis, and this may be explained by sustained lytic ability. Additionally, secondary memory CD8 T cells are more permissive than primary memory CD8 T cells for new T cell priming in lymph nodes, possibly suggesting a mechanism of replacement for memory T cells. Thus, primary and secondary memory CD8 T cells are functionally distinct, and the number of encounters with antigen influences memory CD8 T cell function.

T-Lymphocyte Subsets - immunology

CD8-Positive T-Lymphocytes - cytology

T-Lymphocyte Subsets - cytology

Coculture Techniques

Mice, Inbred C57BL

Cells, Cultured

Immunophenotyping

Mice, Transgenic

L-Selectin - genetics

Listeria monocytogenes - immunology

CD8-Positive T-Lymphocytes - classification

L-Selectin - biosynthesis

Cell Differentiation - immunology

Animals

Immunologic Memory

T-Lymphocyte Subsets - classification

Mice

Mice, Inbred BALB C

CD8-Positive T-Lymphocytes - immunology

Details

Title: Subtitle: Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype
Creators: Ali Jabbari - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
John T Harty
Resource Type: Journal article
Publication Details: The Journal of experimental medicine, Vol.203(4), pp.919-932
Publisher: United States
DOI: 10.1084/jem.20052237
PMID: 16567385
PMCID: PMC2118270
ISSN: 0022-1007
eISSN: 1540-9538
Grant note: R01 AI050073 / NIAID NIH HHS AI50073 / NIAID NIH HHS R37 AI042767 / NIAID NIH HHS AI059752 / NIAID NIH HHS R01 AI046653 / NIAID NIH HHS T32 GM007337 / NIGMS NIH HHS AI42767 / NIAID NIH HHS R01 AI042767 / NIAID NIH HHS R01 AI059752 / NIAID NIH HHS R21 AI042767 / NIAID NIH HHS AI46653 / NIAID NIH HHS
Language: English
Date published: 04/17/2006
Academic Unit: Dermatology; Pathology
Record Identifier: 9984025466202771

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