Journal article
Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection
Clinical Infectious Diseases, Vol.56(6), pp.798-805
2013
DOI: 10.1093/cid/cis1006
PMID: 23223600
Abstract
Background. It is unknown whether rising incidence rates of nosocomial bloodstream infections (BSIs) caused by antibiotic-resistant bacteria (ARB) replace antibiotic-susceptible bacteria (ASB), leaving the total BSI rate unaffected.
Methods. We investigated temporal trends in annual incidence densities (events per 100 000 patient-days) of nosocomial BSIs caused by methicillin-resistant Staphylococcus aureus (MRSA), ARB other than MRSA, and ASB in 7 ARB-endemic and 7 ARB-nonendemic hospitals between 1998 and 2007.
Results. 33 130 nosocomial BSIs (14% caused by ARB) yielded 36 679 microorganisms. From 1998 to 2007, the MRSA incidence density increased from 0.2 to 0.7 (annual increase, 22%) in ARB-nonendemic hospitals, and from 3.1 to 11.7 (annual increase, 10%) in ARB-endemic hospitals ( P = .2), increasing the incidence density difference between ARB-endemic and ARB-nonendemic hospitals from 2.9 to 11.0. The non-MRSA ARB incidence density increased from 2.8 to 4.1 (annual increase, 5%) in ARB-nonendemic hospitals, and from 1.5 to 17.4 (annual increase, 22%) in ARB-endemic hospitals ( P < .001), changing the incidence density difference from −1.3 to 13.3. Trends in ASB incidence densities were similar in both groups ( P = .7). With annual increases of 3.8% and 5.4% of all nosocomial BSIs in ARB-nonendemic and ARB-endemic hospitals, respectively ( P < .001), the overall incidence density difference of 3.8 increased to 24.4.
Conclusions. Increased nosocomial BSI rates due to ARB occur in addition to infections caused by ASB, increasing the total burden of disease. Hospitals with high ARB infection rates in 2005 had an excess burden of BSI of 20.6 per 100 000 patient-days in a 10-year period, mainly caused by infections with ARB.
Details
- Title: Subtitle
- Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection
- Creators
- H S M Ammerlaan - University of Medical Centre Utrecht, NetherlandsS Harbarth - Geneva University Hospital and Medical Sch, SwitzerlandA G M Buiting - John Radcliffe Hospital, EnglandD W Crook - Amphia Hospital, NetherlandsF Fitzpatrick - Beaumont Hospital, IrelandHåkan Hanberger - Infektionskliniken i ÖstergötlandL A Herwaldt - University of Iowa, IA USAP H J van Keulen - Amphia Hospital, NetherlandsJ A J W Kluytmans - St Elizabeth Hospital, NetherlandsA Kola - Charite University of Medical Berlin, GermanyR S Kuchenbecker - University of Federal Rio Grande do Sul, BrazilE Lingaas - University of Oslo, NorwayN Meessen - University of Medical Centre Groningen, NetherlandsM -m Morris-Downes - Beaumont Hospital, IrelandJ M Pottinger - University of Iowa Hospital and Clin, IA USAP Rohner - Geneva University Hospital and Medical Sch, SwitzerlandR P dos Santos - University of Federal Rio Grande do Sul, BrazilH Seifert - University of Cologne, GermanyH Wisplinghoff - University of Cologne, GermanyS Ziesing - Hannover Medical Sch, GermanyA S Walker - John Radcliffe Hospital, EnglandM J M Bonten - University of Medical Centre Utrecht, Netherlands
- Resource Type
- Journal article
- Publication Details
- Clinical Infectious Diseases, Vol.56(6), pp.798-805
- DOI
- 10.1093/cid/cis1006
- PMID
- 23223600
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 2013
- Academic Unit
- Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984094591102771
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