Journal article
Sedation in the intensive care unit
Current opinion in critical care, Vol.8(4), pp.290-298
08/2002
DOI: 10.1097/00075198-200208000-00004
PMID: 12386488
Abstract
Although the administration of sedatives is a commonplace activity in the ICU, few guidelines are available to aid the clinician in this practice. The first principle of sedative administration is to define the specific problem requiring sedation and to rationally choose the drug and depth of sedation appropriate for the indication. Next, the clinician must recognize the diverse and often unpredictable effects of critical illness on drug pharmacokinetics and pharmacodynamics. Failure to recognize these effects may lead initially to inadequate sedation and subsequently to drug accumulation. Drug accumulation may result in prolonged encephalopathy and mechanical ventilation and may mask the development of neurologic or intra-abdominal complications. Daily interruption of continuous sedative infusions is a simple and effective way of addressing this problem. A glossary of sedative drugs commonly used in the ICU is included in this review.
Details
- Title: Subtitle
- Sedation in the intensive care unit
- Creators
- Brian K Gehlbach - Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USAJohn P Kress
- Resource Type
- Journal article
- Publication Details
- Current opinion in critical care, Vol.8(4), pp.290-298
- Publisher
- United States
- DOI
- 10.1097/00075198-200208000-00004
- PMID
- 12386488
- ISSN
- 1070-5295
- eISSN
- 1531-7072
- Language
- English
- Date published
- 08/2002
- Academic Unit
- Neurology; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984020730802771
Metrics
16 Record Views