Journal article
Sedentary Behaviors and Venous Thromboembolism Risk among Older Women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study
Journal of thrombosis and haemostasis, Vol.23(5), pp.1636-1647
05/2025
DOI: 10.1016/j.jtha.2025.02.014
PMCID: PMC12217680
PMID: 39986610
Abstract
Venous stasis, which can occur with prolonged sedentary behavior (SB), is associated with venous thromboembolism (VTE) risk, but VTE risk associated with accelerometer-measured SB has not been quantified.
To evaluate accelerometer-based measures of SB in relation to incident VTE.
We included 5,591 participants, aged 63-99 years, of the Women's Health Initiative Objective Physical Activity and Cardiovascular Health cohort study without prior VTE. Between May 2012-2014, participants wore the ActiGraph GT3X+ accelerometer at the hip for 7 days. Three SB measures were classified using the Convolutional Neural Network Hip Accelerometer Posture algorithm: total sitting time, mean sitting bout duration, and total time spent in prolonged (≥30 minute) sitting bouts. VTE events were centrally adjudicated. Multivariable-adjusted Cox models estimated hazard ratios (HRs) for each SB and VTE risk. Women were censored at first VTE, death, loss to follow-up, or February 2023. Mediation by body mass index (BMI) was evaluated.
Over a mean follow-up of 8.2 years, 229 women experienced a VTE. In adjusted models, longer mean sitting bout duration was associated with greater incident VTE risk (HR per 5-minute increase=1.15; 95% CI: 1.04, 1.28). BMI mediated approximately 30% of this association (p<0.01). We found no significant evidence that total sitting time or total time spent in prolonged sitting bouts were associated with VTE.
Longer mean sitting bout duration was associated with greater VTE risk, with substantial mediation by BMI. Behavioral efforts to reduce sedentary bout length in older women may reduce their VTE risk.
Details
- Title: Subtitle
- Sedentary Behaviors and Venous Thromboembolism Risk among Older Women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study
- Creators
- Laura B Harrington - Kaiser Permanente Washington Health Research InstituteKara L Cushing-Haugen - Kaiser Permanente Washington Health Research InstituteSteve Nguyen - Human Longevity (United States)John Bellettiere - Human Longevity (United States)Michael J LaMonte - University at Buffalo, State University of New YorkCharles B Eaton - Brown UniversityMatthew A Allison - University of California San DiegoRobert B Wallace - University of IowaJoAnn E Manson - Brigham and Women's HospitalMajken K Jensen - University of CopenhagenChristopher Kabrhel - Massachusetts General HospitalGregory A Wellenius - Boston UniversityI-Min Lee - Brigham and Women's HospitalKenneth J Mukamal - Beth Israel Deaconess Medical CenterAndrea Z LaCroix - University of California San Diego
- Resource Type
- Journal article
- Publication Details
- Journal of thrombosis and haemostasis, Vol.23(5), pp.1636-1647
- DOI
- 10.1016/j.jtha.2025.02.014
- PMID
- 39986610
- PMCID
- PMC12217680
- NLM abbreviation
- J Thromb Haemost
- ISSN
- 1538-7836
- eISSN
- 1538-7836
- Publisher
- ELSEVIER SCIENCE INC
- Grant note
- National Heart, Lung, and Blood Institute: K01HL139997, R01HL105065, R01HL153462 National Institute on Aging: K24AG065525, K99AG082863 National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services: 75N92021D00001, 75N92021D00004, 75N92021D00005, 75N92021D00002, 75N92021D00003
The present study was supported by the National Heart, Lung, and Blood Institute (grants K01HL139997 to L.B.H. and R01HL105065 and R01HL153462 to A.Z.L.) and the National Institute on Aging (K24AG065525 to K.J.M. and K99AG082863 to S.N.) . The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005.
- Language
- English
- Electronic publication date
- 02/20/2025
- Date published
- 05/2025
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984792368502771
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