Journal article
Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma
American journal of otolaryngology, Vol.40(3), pp.448-452
05/01/2019
DOI: 10.1016/j.amjoto.2019.03.005
PMID: 30885449
Abstract
Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated to the radiated laryngopharynx. Mucosal MCC is rare and radiation-induced MCC has been hypothesized to occur in previously radiated tissue but, never before to the laryngopharynx. Implications regarding cancer biology and management is focused with discussion on relevant advances in pathologic assessment and immunotherapy.
Details
- Title: Subtitle
- Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma
- Creators
- Monica K. Rossi - University of Iowa Hospitals and ClinicsD. Anand Rajan Kanagasabapathy - University of Iowa Hospitals and ClinicsHenry T. Hoffman - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- American journal of otolaryngology, Vol.40(3), pp.448-452
- DOI
- 10.1016/j.amjoto.2019.03.005
- PMID
- 30885449
- NLM abbreviation
- Am J Otolaryngol
- ISSN
- 0196-0709
- eISSN
- 1532-818X
- Publisher
- Elsevier
- Number of pages
- 5
- Language
- English
- Date published
- 05/01/2019
- Academic Unit
- Pathology; Radiation Oncology; Otolaryngology
- Record Identifier
- 9984311445502771
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