Journal article
Segmentation of the optic disc in 3-D OCT scans of the optic nerve head
IEEE transactions on medical imaging, Vol.29(1), pp.159-168
01/2010
DOI: 10.1109/TMI.2009.2031324
PMCID: PMC2911797
PMID: 19758857
Abstract
Glaucoma is the second leading ocular disease causing blindness due to gradual damage to the optic nerve and resultant visual field loss. Segmentations of the optic disc cup and neuroretinal rim can provide important parameters for detecting and tracking this disease. The purpose of this study is to describe and evaluate a method that can automatically segment the optic disc cup and rim in spectral-domain 3-D OCT (SD-OCT) volumes. Four intraretinal surfaces were segmented using a fast multiscale 3-D graph search algorithm. After surface segmentation, the retina in each 3-D OCT scan was flattened to ensure a consistent optic nerve head shape. A set of 15 features, derived from the segmented intraretinal surfaces and voxel intensities in the SD-OCT volume, were used to train a classifier that can determine which A-scans in the OCT volume belong to the background, optic disc cup and rim. Finally, prior knowledge about the shapes of the cup and rim was incorporated into the system using a convex hull-based approach. Two glaucoma experts annotated the cup and rim area using planimetry, and the annotations of the first expert were used as the reference standard. A leave-one-subject-out experiment on 27 optic nerve head-centered OCT volumes (14 right eye scans and 13 left eye scans from 14 patients) was performed. Two different types of classification methods were compared, and experimental results showed that the best performing method had an unsigned error for the optic disc cup of 2.52+/-0.87 pixels (0.076+/-0.026 mm) and for the neuroretinal rim of 2.04+/-0.86 pixels (0.061+/-0.026 mm). The interobserver variability as indicated by the unsigned border positioning difference between the second expert observer and the reference standard was 2.54+/-1.03 pixels (0.076+/-0.031 mm for the optic disc cup and 2.14+/-0.80 pixels (0.064+/-0.024 mm for the neuroretinal rim. The unsigned error of the best performing method was not significantly different (p > 0.2) from the interobserver variability.
Details
- Title: Subtitle
- Segmentation of the optic disc in 3-D OCT scans of the optic nerve head
- Creators
- Kyungmoo Lee - Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA 52242, USA. kyungmle@engineering.uiowa.eduMeindert NiemeijerMona K GarvinYoung H KwonMilan SonkaMichael D Abramoff
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on medical imaging, Vol.29(1), pp.159-168
- DOI
- 10.1109/TMI.2009.2031324
- PMID
- 19758857
- PMCID
- PMC2911797
- NLM abbreviation
- IEEE Trans Med Imaging
- ISSN
- 0278-0062
- eISSN
- 1558-254X
- Publisher
- Institute of Electrical and Electronics Engineers; United States
- Grant note
- R01 EB004640 / NIBIB NIH HHS EY017066 / NEI NIH HHS R01 EY017066 / NEI NIH HHS R01 EB004640-04 / NIBIB NIH HHS R01 EY019112 / NEI NIH HHS EB004640 / NIBIB NIH HHS R01 EY017066-04 / NEI NIH HHS R01 EY019112-01A2 / NEI NIH HHS R01 EY018853-01A2 / NEI NIH HHS R01 EY018853 / NEI NIH HHS R01 EB004640-06 / NIBIB NIH HHS
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983806399802771
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