Journal article
Seizure Detection: Interreader Agreement and Detection Algorithm Assessments Using a Large Dataset
Journal of clinical neurophysiology, Vol.38(5), pp.439-447
09/01/2021
DOI: 10.1097/WNP.0000000000000709
PMCID: PMC8404956
PMID: 32472781
Abstract
Purpose: To compare the seizure detection performance of three expert humans and two computer algorithms in a large set of epilepsy monitoring unit EEG recordings. Methods: One hundred twenty prolonged EEGs, 100 containing clinically reported EEG-evident seizures, were evaluated. Seizures were marked by the experts and algorithms. Pairwise sensitivity and false-positive rates were calculated for each human-human and algorithm-human pair. Differences in human pairwise performance were calculated and compared with the range of algorithm versus human performance differences as a type of statistical modified Turing test. Results: A total of 411 individual seizure events were marked by the experts in 2,805 hours of EEG. Mean, pairwise human sensitivities and false-positive rates were 84.9%, 73.7%, and 72.5%, and 1.0, 0.4, and 1.0/day, respectively. Only the Persyst 14 algorithm was comparable with humans-78.2% and 1.0/day. Evaluation of pairwise differences in sensitivity and false-positive rate demonstrated that Persyst 14 met statistical noninferiority criteria compared with the expert humans. Conclusions: Evaluating typical prolonged EEG recordings, human experts had a modest level of agreement in seizure marking and low false-positive rates. The Persyst 14 algorithm was statistically noninferior to the humans. For the first time, a seizure detection algorithm and human experts performed similarly.
Details
- Title: Subtitle
- Seizure Detection: Interreader Agreement and Detection Algorithm Assessments Using a Large Dataset
- Creators
- Mark L. Scheuer - Persyst Development Corporation, Solana Beach, California, U.S.A.Scott B. Wilson - Persyst Development Corporation, Solana Beach, California, U.S.A.Arun Antony - Comprehensive Epilepsy CenterGena Ghearing - University of IowaAlexandra Urban - Comprehensive Epilepsy CenterAnto Bagic - Comprehensive Epilepsy Center
- Resource Type
- Journal article
- Publication Details
- Journal of clinical neurophysiology, Vol.38(5), pp.439-447
- DOI
- 10.1097/WNP.0000000000000709
- PMID
- 32472781
- PMCID
- PMC8404956
- NLM abbreviation
- J Clin Neurophysiol
- ISSN
- 0736-0258
- eISSN
- 1537-1603
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- Persyst Development Corporation
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Neurology
- Record Identifier
- 9984303019802771
Metrics
16 Record Views