Journal article
Seizures in Extremely Low Birth Weight Infants Are Associated with Adverse Outcome
The Journal of pediatrics, Vol.157(5), pp.720-725.e2
2010
DOI: 10.1016/j.jpeds.2010.04.065
PMCID: PMC2939969
PMID: 20542294
Abstract
To examine risk factors for neonatal clinical seizures and to determine the independent association with death or neurodevelopmental impairment (NDI) in extremely low birth weight (ELBW) infants.
A total of 6499 ELBW infants (401-1000 g) surviving to 36 weeks postmenstrual age (PMA) were included in this retrospective study. Unadjusted comparisons were performed between infants with (n = 414) and without (n = 6085) clinical seizures during the initial hospitalization. Using multivariate logistic regression modeling, we examined the independent association of seizures with late death (after 36 weeks PMA) or NDI after controlling for multiple demographic, perinatal, and neonatal variables.
Infants with clinical seizures had a greater proportion of neonatal morbidities associated with poor outcome, including severe intraventricular hemorrhage, sepsis, meningitis, and cystic periventricular leukomalacia (all
P < .01). Survivors were more likely to have NDI or moderate-severe cerebral palsy at 18 to 22 months corrected age (both
P < .01). After adjusting for multiple confounders, clinical seizures remained significantly associated with late death or NDI (odds ratio, 3.15; 95% CI, 2.37-4.19).
ELBW infants with clinical seizures are at increased risk for adverse neurodevelopmental outcome, independent of multiple confounding factors.
Details
- Title: Subtitle
- Seizures in Extremely Low Birth Weight Infants Are Associated with Adverse Outcome
- Creators
- Alexis S Davis - Division of Neonatal-Developmental Medicine, Stanford University, Stanford, CASusan R Hintz - Division of Neonatal-Developmental Medicine, Stanford University, Stanford, CAKrisa P Van Meurs - Division of Neonatal-Developmental Medicine, Stanford University, Stanford, CALei Li - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NCAbhik Das - Statistics and Epidemiology Unit, RTI International, Rockville, MDBarbara J Stoll - Department of Pediatrics, Emory University School of Medicine, Atlanta, GAMichele C Walsh - Department of Pediatrics, Case Western Reserve University, Cleveland, OHAthina Pappas - Department of Pediatrics, Wayne State University, Detroit, MIEdward F Bell - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IAAbbot R Laptook - Department of Pediatrics, Brown University, Providence, RIRosemary D Higgins - Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MDEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.157(5), pp.720-725.e2
- DOI
- 10.1016/j.jpeds.2010.04.065
- PMID
- 20542294
- PMCID
- PMC2939969
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Mosby, Inc
- Grant note
- National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) for the Neonatal Research Network's Generic Database Study and Follow-up Study
- Language
- English
- Date published
- 2010
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093328402771
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