Selected inflammatory imitators of mycosis fungoides: histologic features and utility of ancillary studies

David P Arps; Stephanie Chen; Douglas R Fullen; Alexandra C Hristov

doi:10.5858/arpa.2014-0298-CC

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Selected inflammatory imitators of mycosis fungoides: histologic features and utility of ancillary studies

Journal article

Peer reviewed

Selected inflammatory imitators of mycosis fungoides: histologic features and utility of ancillary studies

David P Arps, Stephanie Chen, Douglas R Fullen and Alexandra C Hristov

Archives of pathology & laboratory medicine (1976), Vol.138(10), pp.1319-1327

10/2014

DOI: 10.5858/arpa.2014-0298-CC

PMID: 25268195

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Abstract

Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Moreover, an appropriate clinical presentation is essential to the diagnosis and helps to favor or exclude inflammatory/reactive processes. Herein, we discuss 3 important inflammatory dermatoses that may closely simulate mycosis fungoides, and we review the use of ancillary studies in these challenging cases.

Dermatitis, Allergic Contact - immunology

Mycosis Fungoides - immunology

Lichen Sclerosus et Atrophicus - genetics

Prognosis

Drug Eruptions - pathology

Humans

Lichen Sclerosus et Atrophicus - diagnosis

Male

Dermatitis, Allergic Contact - pathology

Lichen Sclerosus et Atrophicus - physiopathology

Mycosis Fungoides - pathology

Drug Eruptions - diagnosis

Skin Neoplasms - diagnosis

Pseudolymphoma - chemically induced

Adult

Drug Eruptions - immunology

Pseudolymphoma - diagnosis

Skin - pathology

Mycosis Fungoides - diagnosis

Skin - immunology

Skin Neoplasms - pathology

Diagnosis, Differential

Lichen Sclerosus et Atrophicus - pathology

Skin Neoplasms - immunology

Pseudolymphoma - pathology

Pseudolymphoma - immunology

Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor

Dermatitis, Allergic Contact - diagnosis

Phimosis - etiology

Details

Title: Subtitle: Selected inflammatory imitators of mycosis fungoides: histologic features and utility of ancillary studies
Creators: David P Arps - From the Departments of Pathology (Drs Arps, Chen, Fullen, and Hristov) and Dermatology (Drs Fullen and Hristov), University of Michigan, Ann Arbor
Stephanie Chen
Douglas R Fullen
Alexandra C Hristov
Resource Type: Journal article
Publication Details: Archives of pathology & laboratory medicine (1976), Vol.138(10), pp.1319-1327
Publisher: United States
DOI: 10.5858/arpa.2014-0298-CC
PMID: 25268195
ISSN: 0003-9985
eISSN: 1543-2165
Language: English
Date published: 10/2014
Academic Unit: Pathology
Record Identifier: 9984047891102771

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